Online tutorial

InterPro

A case study of 3 protein family building methodologies

Time to complete:

1 hour

This course includes:

  • Activities
  • Quizzes
  • Videos

Written by:

Last reviewed:

February 2025


Creative Commons

All materials are free cultural works licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, except where further licensing details are provided.


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This course provides an insight into the different protein family building methodologies employed by three InterPro member databases, namely SFLD (Structure Function Linkage Database), TIGRFAMs and PANTHER. It also describes an automated approach to comparing protein signatures and predicting hierarchical relationships between them.

Feedback and help

Who is this course for?

This course is for anyone who would like to learn about different protein family building methodologies used by InterPro databases. An undergraduate-level knowledge of biology would be an advantage when taking these courses.

For a brief introduction to InterPro please see our InterPro Quick Tour, or for more information about the InterPro resource please see our InterPro Tutorial. If you are new to the field of protein biology then we recommend that you first take our course Protein classification: An introduction to EMBL-EBI resources

What will I achieve?

By the end of the course you will be able to:

  • Identify differences and similarities in methodologies of protein signature creation by SFLD, TIGRFAMs and PANTHER
  • Illustrate how protein signatures can be compared to predict relationships between them

What resources do I need?

There are no specific resources required to complete this course.

DOI: 10.6019/TOL.InterProFam-t.2018.00001.1