- Course overview
- Search within this course
- What is the IMPC?
- How is IMPC data generated?
- Translating to other species and learning about human disease
- The home page of the IMPC website
- Searching for a gene of interest
- Gene pages
- Chart pages
- Searching for phenotypes
- Phenotype pages
- Late Adult data
- Image data
- Data downloads
- Quiz: check your learning
- Summary
- Your feedback
- Get help and support on the IMPC
- References
All materials are free cultural works licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, except where further licensing details are provided.
Did you know… you can find more significant parameters than significant phenotypes?
Understanding the signficant phenotypes results
How many significant phenotypes are associated with a given physiological system? What parameters were significant?
Answer:
In the gene page for Tmem63b, we can sort the significant phenotypes by System (Figure 33).
We observe that there are 3 nervous system significant genotype-phenotype associations:
- limb grasping
- decreased vertical activity
- hyperactivity
Next, we can click on the tab All data table. Here we can find and browse for all data the IMPC has found associated to this gene. We can download this table, too.
Here we filter for the nervous system, for example, and sort by significant parameters first by clicking on the header of the column Significant (Figure 34). Note that we find seven significant parameters but three significant phenotypes.
If you click on hyperactivity on the Significant Phenotypes table (Figure 33), you will see the chart pages for the tests that resulted in an association with the phenotype hyperactivity.
| NOTE THAT… You can find more significant parameters than phenotypes when more than one parameter is annotated to the same phenotype. |
| NOTE THAT… You can learn about significant as well as non-significant results in the All data table, enabling users to find answers to questions like what parameters were measured but results were not significant, were homozygotes as well as heterozygotes measured, how many lines were phenotyped, etc. |