The International Mouse Phenotyping Consortium Finding phenotypes for your gene of interest
The International Mouse Phenotyping Consortium (IMPC) portal provides a freely available comprehensive catalogue of mammalian gene function, using the mouse as a model. By applying a standardised phenotyping pipeline to single-gene knockout mouse lines, the IMPC identifies the physiological systems that are disrupted when a gene is disabled and thus establish gene-phenotype associations. This course will show you how to navigate the IMPC portal to find phenotypes, disease models and knockout mouse strains for a gene of interest.
Who is this course for?
This course is suitable for those with an undergraduate-level knowledge of biology. If you are new to the field of genetic variation then we recommend that you start with our course Human genetic variation I: an introduction to familiarise yourself with some of the key concepts and terms used in the field.
If you’d like to listen to a talk describing the exciting discoveries the IMPC is making using these data, please have a look at the webinar The International Mouse Phenotyping Consortium (IMPC): a large-scale functional catalogue of mammalian genes.
What will I achieve?
By the end of the course you will be able to:
- Describe what the IMPC is and what data you can find within the IMPC portal
- Determine whether there are phenotypes and/or potential disease models for your gene of interest
- Identify whether there are genes associated with a phenotype you are interested in
- Establish whether there are knockout mouse strains available for your gene of interest and know how to order them
What resources do I need?
There are no specific resources required to complete this course.
- What is the IMPC?
- How is IMPC data generated?
- Navigating the IMPC portal
- Try it yourself
- Quiz: check your learning
- Your feedback
- Get help and support on the IMPC
How and when to access the course
All our courses are designed with flexibility in mind. You can access them for free at any time, just click on the “Enter Course” button.
It is up to you how you use the course; you can either study the full course or you can focus on sections that are relevant to you. To jump between sections, use the navigation bar on the left or the arrows at the bottom of the page. You can also choose whether to complete the course in one go, or over several visits.
The average time to read through the main body of the course is 1 hour (not including exercises and external links). The time may vary depending on your prior knowledge and how you choose to work through the course.
Making the most of the course
Learning something new takes time and practice. We encourage you to:
- Use the activities and quizzes to help you check your learning, recall and apply key concepts. Look out for these icons:-
Activities Quizzes Videos
- Revisit sections as and when you need them. Bookmark relevant pages in your browser or use the navigation panel to jump the relevant section.
Getting help and providing feedback
If something isn’t working or if you have a question get in touch by contacting us at firstname.lastname@example.org
Tell us what you thought about the course (both good and bad!) using the “Feedback and help” button found at the top of each page.
Your feedback helps us ensure we are providing training that is relevant and useful for you.
For help and support on EMBL-EBI resources you can contact the helpdesk directly.
You can explore other training on offer from EMBL-EBI on our website. We offer online courses, webinars, face-to-face courses and offsite training.