Online tutorial

The International Mouse Phenotyping Consortium

Finding phenotypes for your gene of interest

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Time to complete:

1 hour

This course includes:

  • Activities
  • Quizzes
  • Videos

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Last reviewed:

April 2022

Creative Commons

All materials are free cultural works licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, except where further licensing details are provided.

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The International Mouse Phenotyping Consortium (IMPC) portal provides a freely available comprehensive catalogue of mammalian gene function, using the mouse as a model. By applying a standardised phenotyping pipeline to single-gene knockout mouse lines, the IMPC identifies the physiological systems that are disrupted when a gene is disabled and thus establish gene-phenotype associations. This course will show you how to navigate the IMPC portal to find phenotypes, disease models and knockout mouse strains for a gene of interest. 

Feedback and help

Who is this course for?

This course is suitable for those with an undergraduate-level knowledge of biology. If you are new to the field of genetic variation then we recommend that you start with our course Human genetic variation I: an introduction to familiarise yourself with some of the key concepts and terms used in the field.

If you’d like to listen to a talk describing the exciting discoveries the IMPC is making using these data, please have a look at the webinar The International Mouse Phenotyping Consortium (IMPC): a large-scale functional catalogue of mammalian genes.

What will I achieve?

By the end of the course you will be able to:

  • Describe what the IMPC is and what data you can find within the IMPC portal
  • Determine whether there are phenotypes and/or potential disease models for your gene of interest
  • Identify whether there are genes associated with a phenotype you are interested in
  • Establish whether there are knockout mouse strains available for your gene of interest and know how to order them

What resources do I need?

There are no specific resources required to complete this course.

DOI: 10.6019/TOL.IMPC-t.2014.00001.1

Course contents