Common study types in functional genomics

Functional genomics experiments measure changes in the DNA (genome and epigenome), RNA (transcriptome), or interactions between DNA/RNA and proteins that influence the phenotype of a sample. Common branches of functional genomics include (Figure 8):

  • genotyping
  • transcription profiling
  • epigenetic profiling
  • nucleic acid-protein interactions
  • meta-analysis
The molecules that can be analysed by functional genomics and the technologies used in the analysis
Figure 8 The molecules that can be analysed by functional genomics and the technologies used in the analysis. Reprinted by permission from Macmillan Publishers Ltd: Nature Biotechnology. Shendure J and Lieberman E. The expanding scope of DNA sequencing. 30:1084-94, copyright 2012 (8).

Over the next few pages, you will find more information and examples for each of those.