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Bioinformatics for the terrified

An introduction to the science of bioinformatics

    • Course overview
    • Search within this course
    • What is bioinformatics?
      • Who is bioinformatics for?
    • The role of public databases
      • Data sharing collaborations
    • What makes a good bioinformatics database?
      • Primary and secondary databases
      • Describing data consistently
      • Minimum information standards
      • Controlled vocabularies
        • Non-hierarchical list
        • Taxonomy
        • Thesaurus
        • Using ontologies to provide controlled vocabularies
        • Gene Ontology
      • Check your learning
    • Managing and sharing data
      • A few tips on data sharing
      • Where do I submit my data?
      • When is open sharing not appropriate?
    • Bioinformatics as an experimental science
      • Searching
        • Guided example 1: ZAP70 as a potential target for immunosuppressive therapy
        • Searching for ZAP70 using EBI-search
        • Check your learning
      • Comparing
        • Guided example 2: does sheep ZAP70 have an active tyrosine kinase?
        • Examining the ZAP70 sequence with InterProScan
      • Modelling
        • Guided example 3 – building a protein structural model
        • Solution 1: Retrieving IRAK2 3D structure using AlphaFold DB
        • Solution 2: downloading the sequence of human IRAK2 and build the 3D model
      • Integrating
        • Basic principles of integration
    • Summary
    • Your feedback
    • Learn more
    • References

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