Structural volume data


This course provides a basic introduction to volume matching techniques in the field of structural bioinformatics. It explains the use of electron microscopy (EM) and electron tomography (ET) data in creating 3D volume maps of proteins, and the approaches that can be used to compare volumes. It describes how volume matching can be used to find similar structures, or to highlight specific differences between related structures.

This module requires an understanding of modern structural bioinformatics techniques. An appreciation for advanced modelling techniques would also be useful.

This e-learning training module was developed as part of the BioMedBridges project, funded by FP7 Capacities Specific Programme, grant agreement no. 284209.


European CommissionFP7

About this course

Martyn Winn
Learning objectives: 
  • Gain an understanding of what structural volume data is
  • Appreciate the value of volume data even in the absence of atomic coordinates
  • Comprehend the variety of methods available to compare volumes
  • Appreciate the limitations of available scores