When to use ENA

 You can use ENA if you:

  • have a gene or transcript of interest and you would like to know its sequence;
  • would like to know about non-coding sequence found between genes (intergenic regions);
  • want to explore a region around a gene of interest to find neighbouring genes;
  • want to know how a gene, transcript or region was assembled into one contiguous sequence;
  • want to identify orthologues of a gene in other species, or paralogues within a species;
  • want to know about any sequence variations associated with a disease or mutational study;
  • want to fetch a batch of sequences for analysis and study, including via programmatic access;
  • want to see what sequence data is available for a specific organism;
  • have an interest in a project, such as a metagenomics project, and you want to see all the sequence data they have generated;
  • would like to know the sequence associated with a chromosomal rearrangement, such as the Philadelphia 22q11 chromosome associated with leukaemia;


 ENA would not be your first choice if you:

  • are interested in comprehensive genomic information, it is better to use the genome browser Ensembl or Ensembl Genomes, which puts sequence data into context with additional annotation not in ENA;
  • are interested in patent sequences, it is better to use the Non-redundant Patent Sequence Databases, because they contain all the patent sequences found in ENA plus additional unique sequences and patent-specific information.