Finding information on transgenic sequences


An image of a mosquito


Malaria accounts for over 2% of the world's deaths. Female mosquitoes of the Anopheles  genus are the primary hosts as they require a blood meal to develop eggs, the males feeding on nectar rather than blood. When a female ingests infected blood, malarial sporozoites develop in her gut before migrating to the salivary glands. When the mosquito next feeds, malarial parasites in the saliva are transmitted into the skin. As resistance to anti-malarial drugs becomes an increasing problem, researchers have tried other approaches, such as trying to prevent malarial parasites from invading mosquito salivary glands in order to break the infection cycle.


You want to investigate the interactions between mosquitoes and malaria-causing parasites. You found an interesting paper detailing work done with Anopheles stephensi, an Asian species of malarial mosquito, on salivary gland-parasite interactions. You would like to look at the genetic constructs they used in order to design your own experiments involving other species from the Anopheles  genus. For this, you need to know the details of the genetic construct they used. The paper mentions that the nucleotide data for their transgenic construct was deposited to GenBank under the accession number 'AB212907'.

  • From which organism does each region of the transgenic sequence originate?

  • What feature(s) are described for each sequence region?

  • Give the nucleotide ranges for each sequence region.

  • If the accession number 'AB212907' was not known, could you think of another way of finding this entry?