Topological PPIN analysis

Analysing the topological features of a network is a useful way of identifying relevant participants and substructures that may be of biological significance. There are many different strategies that can be used to do this (Figure 26). In this section we focus on centrality analysis and topological clustering, although there are other strategies such as the search for shortest paths or motifs that are more often applied to networks with directionality and will not be covered here.

Methods for finding substructures in networks

Figure 26 Common structural analysis strategies for PPINs.