Want to know how we did it?
When you search InterPro with the FASTA sequence provided, you will get a graphical representation of results, similar to that shown in Figure 24.
Figure 24. InterPro sequence search results overview page.
From the results in InterPro you can infer:
- That the protein is predicted to contain an N-terminal signalling domain, which is part of a wider class of domains that also includes the zinc-binding domains of DD-peptidase.
- That the protein is also predicted to contain a C-terminal Hint domain, which is involved in autoprocessing of the protein. The Hint domain itself can be broken down into two smaller subdomains.
- That the protein queried is predicted to a member of the hedgehog protein family, and therefore involved in a range of biological processes, including development and cell-cell signalling. How? From the GO terms and description from entry IPR001657 (see Figure 25 below).
Figure 25. The InterPro entry page for IPR001657 (Hedgehog protein).