Why do we need the IMPC portal?

 

A powerful organism for studying human disease

The laboratory mouse has become one of the most important research tools to enhance our understanding of mammalian gene function. The genetic, physiological and anatomical similarity to humans, coupled with our ability to directly manipulate the mouse genome, has made the mouse an extremely powerful organism to study human disease.

By creating a knockout mouse line for each protein-coding gene and performing high-throughput phenotyping of these lines, the IMPC is aiming to determine the function of every gene in the mouse genome. This will help drive new ideas and underpinning future research into biological systems. 

Making strains publically available

In addition to providing phenotypic data, these mouse strains are preserved in repositories and made available to the scientific community - providing a valuable resource for basic scientific research and for generating new models of human diseases.