What is the Complex Portal?

What is the Complex Portal?

The Complex Portal is a manually curated, encyclopedic resource of macromolecular complexes from a number of key model organisms, entered into the IntAct molecular interaction database. Data include protein-only complexes, as well as protein-small molecule and protein-nucleic acid complexes. All complexes are either derived from:

1) physical molecular interaction evidence extracted from the literature


2) inferred by curators: either from information on orthologues in closely-related species, paralogues in the same species or from background biological knowledge based on other evidence (for example, pharmacological studies). 

All complexes are tagged using controlled vocabulary terms from the Evidence Code Ontology.

The Complex Portal contains an interactive viewer with details of stoichiometry and binding regions. It provides cross-references to the complex from many other databases, such as The PDB, Reactome and ChEMBL. The portal also contains annotations to all three classes of The Gene Ontology, EC numbers, diseases and literature evidence.

Content is added by expert curators and direct user requests are prioritised. 

Why do we need the Complex Portal?

The Complex Portal provides annotations for the complex (= the functional biological entity), along with desciptions of their function and other properties. It differs from UniProt because the latter only provides annotations for the protein subunits.