Other ChEMBL databases

 

ChEMBL-NTD

You can search for data on neglected tropical diseases using the ChEMBL-NTD interface. For instance, ChEMBL-NTD contains a dataset of 13,500 compounds that are known to inhibit the growth of the Plasmodium falciparum strain 3D7, which is one of the most deadly parasites that causes malaria in humans. This dataset was donated by GlaxoSmithKline (GSK). Since then, a number of other companies have donated their data, such as Novartis, Harvard Medical School and St. Jude Children's Research Hospital (Figure 25).

Figure 25 Example datasets from ChEMBL-NTD.

The SARfaris

The SARfaris (ADME SARfari, Kinase SARfari, GPCR SARfari) enable in-depth searching and analysis of target class data. You can:

  • browse families;
  • search for specific proteins or chemical (sub)structures and view binding sites;
  • make comparisons with other related sequences and retrieve 3D structural data (Figure 26).
Figure 26 ADME SARfari.