Mobilome annotation
Trainer: Alejandra Escobar-Zepeda
Overview: The lecture addresses the biological side of mobile genetic elements (MGEs) annotation in prokaryotes. These elements, found within the genomes of bacteria and archaea, play pivotal roles in the dynamics of microbial communities and the evolution of their hosts. The lecture explores the diverse types of MGEs and discusses their genomic configurations and genetic features; the lecture also reviews the challenges of defining their classification boundaries and the interplay between these elements and host defence systems. In addition, the lecture explores different types of MGE co-evolution, their interactions, and their profound impacts on host genetics and phenotypes.
Learning outcomes:
After this session you should be able to:
- Identify types of mobile genetic elements in prokaryotes
- Describe co-evolution and cross-talk across the mobilome, and summarise host-response to alien DNA
- Summarise MGEs impact in the host geno- and phenotype and MGEs in the microbial community
- Review MGnify’s mobilome annotation pipeline
Materials: