Open Targets platform: integrating omics data for drug discovery
Trainer: Helena Cornu and Kostas Tsirigos
Overview:
The Open Targets Platform – https://platform.opentargets.org/ – is a comprehensive research tool that supports systematic identification and prioritisation of potential therapeutic drug targets. By integrating publicly available datasets along with data generated by the Open Targets consortium, the Platform builds and scores target-disease associations. Users can also explore relevant annotation information about targets, diseases, phenotypes, and drugs, as well as their most relevant relationships.
This lecture will provide an overview of the Open Targets Platform, a freely available and actively maintained resource. All data is available through an intuitive user interface, a GraphQL API, and data downloads. Likewise, the pipeline and infrastructure codebases are open-source and can be used to create a self-hosted private instance of the Platform with custom data.
By the end of this lecture you will be able to:
- Identify the types of ‘omics data integrated into the Platform
- Explore target-disease associations and supporting evidence available in the Platform
- List different ways to access the Platform data
Materials: