In this webinar, we will give an overview of how single-cell and spatial genomics technologies are used to address challenges from complex tissue atlases and resolve cellular wiring diagrams of tissues in health and disease. Using multi-modal tissue atlassing from scRNA-seq, Visium and Xenium, we demonstrate the power to discover the rules of two neurological conditions. First, leveraging single-cell spatial transcriptomics of autism susceptibility genes in the developing human brain, we discovered convergence of genes in thalamic circuits. Second, we present GBM-space, a deeply profiled multi-modal map of glioblastoma tumour tissues across multiple sites, and identified novel cellular and tissue framework unifying glioblastoma tumour heterogeneity. 

This event is part of a broader webinar series on spatial transcriptomics. For more information about the series and its webinars, please visit the following link:  “Decoding spatial transcriptomics through sequences, pixels, and bioinformatics”.

Who is this course for?

This webinar is suitable for students, biologists, computational biologists and bioinformaticians interested in both imaging-based and sequencing-based spatial transcriptomics (ST). Prior experience in analysing transcriptomic data will be beneficial for fully understanding and following the webinar. 

Outcomes

By the end of this webinar, you will be able to:

• Describe sequencing-based and imaging-based spatial transcriptomics platforms.
• Identify common challenges, including quality control, cell type deconvolution/mapping, cell segmentation of ST data.
• Compare bioinformatics methods to integrate single-cell and ST atlases and derive new biological insights.

This webinar, hosted on Zoom Webinar, is free to attend, but you need to register for a place beforehand, using the 'Register' button. Once registered, you will receive a confirmation email with a link to join the webinar.

The webinar will be recorded, and the recording will be made available on this page one day after the event. Please note that we do not issue certificates of attendance for our webinars. However, you will receive an email from our Zoom account confirming your participation a day after the event.