EMBL-EBI Workshop: Mathematics of life workshop: “Modelling molecular mechanisms: from basic science to drug discovery”

Date:

  Wednesday 2 October 2019

Venue: 

Sanders Hall, Postdoc Centre @ Eddington - 105 Eddington Place, Cambridge, Cambridgeshire,  CB3 1AS, United Kingdom

Application opens: 

Thursday 15 August 2019

Application deadline: 

Wednesday 18 September 2019

Participation: 

Open application with selection

Contact: 

Rahuman Sheriff

Registration fee: 

Free

Course Overview

This workshop is open to postdocs in Cambridge, including candidates from University and affiliated institutions

Computer models are increasingly used by researchers as well as pharmaceutical industry to investigate molecular mechanisms disease initiation, progression and therapy. Systems modelling of biochemical pathways deregulated in disease condition offers mechanistic insights into the pathology; helps to elucidate mechanisms behind dug action and predict dose required for treatment and thereby greatly facilitates fundamental research and drug discovery. Such modelling requires background in both molecular biology and mathematics. This workshop will train postdocs from life science and mathematics to communicate and work together to learn to build and analyse computational models using user-friendly open source software. Participant will explore selected computational models from a recent publication, freely available in BioModels repository (www.ebi.ac.uk/biomodels/). 

The one-day workshop includes scientific talks from 3 distinguished speakers who will showcase how modelling is useful in fundamental research as well as pharmaceutical industry, a tutorial session on modelling of normal and disease pathways using simulation software, COPASI, and an extended afternoon hands-on training workshop / group project. Prior knowledge on systems biology modelling not essential.

This course is free to attend and funded by the Office of Postdoctoral Affairs, University of Cambridge.

Audience

The workshop is open to postdocs in Cambridge, including candidates from University and affiliated institutions

Learning outcomes

This workshop will expose participants to computational modelling and help them understand its potential application. It will also train them to collaborate, work together in team and learn from each other to perform interdisciplinary research. Thus, it will be helpful to both postdocs aspiring to become an independent researcher as well as those who plan to transit into pharma industry where modelling is applied in drug discovery.

Programme

8:30 - 9:00 Registration
9:00 - 9:05 Welcome notes
9:05 - 9:50

Prof. Alfonso Martinez Arias, University of Cambridge, Cambridge
Distinguished speaker
Academic talk

9:50 - 10:35 Dr. Lourdes Cucurull-Sanchez, GSK, Stevenage
Distinguished speaker
Industrial talk
10:35 - 10:50 Coffee Break
10:50 - 11:35 Prof. Jasmin Fisher, UCL, London
Distinguished speaker
Academic talk
11:35 - 12:15 Modelling tutorial
12:15- 13:15 Lunch Break
13:15 - 13:30 Introduction to group project
13:30 - 17:30 Group Project
17:30 - 18:20 Project Presentation
18:20 - 18:30 Awards and closing remarks