Date:Thursday 4 - Friday 5 April 2019
Venue:Alexandru Ioan Cuza University - Bulevardul Carol I nr. 11, 700506, Iasi, Romania
Application opens:Thursday 10 January 2019
Application deadline:Sunday 10 March 2019
Participation:Open application with selection
This two-day workshop will introduce participants to bioinformatics approaches for analysis biological data from resources such as UniProt and the PDBe. Day 1 will cover introductory programming in UNIX and python, sequence similarity searching, and how to navigate and use the protein sequence database UniProt. Day 2 will cover methods to access and retrieve data programmatically, the macromolecular structure database Protein Data Bank in Europe, and end with a talk and panel discussion on artificial intelligence’s role in protein structure prediction.
Activities will include interactive presentations and practical exercises delivered by experienced trainers, which will give trainees hands-on experience.
This workshop is aimed at postgraduates (Masters and PhD students) as well as young researchers working with protein sequences and structures.
An undergraduate level understanding of molecular biology and protein structures is necessary. No prior experience of bioinformatics is required.
After this course you should be able to:
- Identify information about all aspects of a protein such as function, interactions and disease association
- Investigate protein homology via sequence similarity searches and alignments
- Use UniProt to connect to specialized resources in different areas of biology
- Search, retrieve and assess the quality of structural data from the PDB archive
- Visualise and analyse structures, including viewing annotations
- View protein-ligand interactions and identify structurally similar proteins
Day 1 – Thursday 4 April 2019
|09:00-09:30||Welcome note and coffee||Organizers|
|09:30-11:00||Introduction to programming: Useful commands in Unix shell and Python||Claudiu Mihăilă|
|11:30-12:30||Introduction to sequence searching and alignments. DNA/RNA vs proteins sequences. Protein sequence and Function||Anna Marobotti|
|13:30-13:45||Introduction to EMBL-EBI resources and tools||Hema Bye-A-Jee|
|13:45-15:30||Protein Sequence Databases: UniProt||Hema Bye-A-Jee|
|16:00-17:00||Protein Sequence Databases: UniProt||Hema Bye-A-Jee|
Day 2 – Friday 5 April 2019
|09:00-10:00||Introduction to programming. Programmatic access to public databases and data retrieval||Claudiu Mihăilă|
|10:30-12:30||Introduction to macromolecular structure at the PDBe||Matt Conroy|
|13:30-15:30||Introduction to macromolecular structure at the PDBe||Matt Conroy|
|16:00-16:30||Talk: Modeling biomolecular structures in the twilight zone and beyond||Andrei-Jose Petrescu|
|16:30-17:00||Panel Discussion: AI’s contribution to construct predictions of protein structures||All speakers and trainers|
|18:30||Beer and science event|
For more information, please see the course webpage on RSBI.ro here.