M-CSA Mechanism and Catalytic Site Atlas

Para-nitrobenzyl esterase (M-CSA:900)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P37967

Reference Sequence	Homologue	His399 Glu310 Ser189 Gly106 (main-N) Ala107 (main-N) Ala190 (main-N)
P37967	P30122	His453 Asp338 Ser212 X X X
P37967	P37967	His399 Glu310 Ser189 Gly106 Ala107 Ala190
P37967	P22394	His482 Glu373 Ser236 X X X
P37967	P04058	His461 Glu348 Ser221 X X X
P37967	P79066	His482 Glu373 Ser236 X X X
P37967	Q6NT32	His454 Glu345 Ser226 X X X
P37967	Q6AW46	His454 Glu345 Ser226 X X X
P37967	Q6AW47	His454 Glu345 Ser226 X X X
P37967	Q5GRG2	His454 Glu345 Ser226 X X X
P37967	Q27459	His468 Glu346 Ser216 X X X
P37967	P37136	His478 Glu365 Ser234 X X X
P37967	Q04791	His460 Glu345 Ser227 X X X
P37967	P19835	His455 Asp340 Ser214 X X X
P37967	B2D0J5	His464 Glu341 Ser212 X X X
P37967	P56161	His504 Glu390 Ser261 X X X
P37967	Q64176	His467 Glu354 Ser222 X X X
P37967	P38433	His468 Glu346 Ser216 X X X
P37967	Q63880	His460 Glu347 Ser232 X X X
P37967	Q64573	His466 Glu353 Ser221 X X X
P37967	P23795	His477 Glu364 Ser233 X X X
P37967	O62763	His475 Glu362 Ser231 X X X
P37967	P22303	His478 Glu365 Ser234 X X X
P37967	O00748	His457 Glu345 Ser228 X X X
P37967	P07140	His518 Glu405 Ser276 X X X
P37967	Q9NDG8	His477 Glu347 Ser219 X X X
P37967	Q91WG0	His459 Glu347 Ser230 X X X
P37967	Q69ZK9	His500 Glu386 Gly265 X X X
P37967	Q9DDE3	His495 Glu352 Ser225 X X X
P37967	P23953	His455 Glu342 Ser221 X X X
P37967	P25727	His470 Asp341 Ser210 X X X
P37967	Q99K10	His525 Glu411 Gly281 X X X
P37967	P81908	His438 Glu325 Ser198 X X X
P37967	Q5XG92	His467 Glu353 Ser221 X X X
P37967	Q04457	His452 Glu319 Ser198 X X X
P37967	Q8QZR3	His456 Glu344 Ser227 X X X
P37967	P14943	His430 Glu318 Ser201 X X X
P37967	P12337	His467 Glu353 Ser221 X X X
P37967	P36196	His633 Glu520 Ser227 X X X
P37967	Q8I034	His454 Glu346 Ser226 X X X
P37967	O62760	His466 Glu353 Ser226 X X X
P37967	P01267	His2620 Asp2515 Arg2387 X X X
P37967	Q62888	His500 Glu386 Gly265 X X X
P37967	P23141	His468 Glu354 Ser221 X X X
P37967	Q8NFZ3	His489 Glu375 Gly254 X X X
P37967	Q6UWW8	His460 Glu347 Ser229 X X X
P37967	Q91WU0	His466 Glu353 Ser221 X X X
P37967	P21927	His445 Glu332 Ser205 X X X
P37967	Q8NFZ4	His500 Glu386 Gly265 X X X
P37967	Q8N2Q7	His522 Glu408 Gly278 X X X
P37967	Q8N0W4	His489 Glu375 Gly254 X X X
P37967	Q29550	His467 Glu354 Ser222 X X X
P37967	Q5RCL7	His458 Glu345 Ser227 X X X
P37967	P16303	His466 Glu353 Ser221 X X X
P37967	Q04456	His451 Glu320 Ser199 X X X
P37967	P32749	His466 Glu353 Ser226 X X X
P37967	P21836	His478 Glu365 Ser234 X X X
P37967	Q8BYM5	His500 Glu386 Gly265 X X X
P37967	Q8R0W5	His475 Glu360 Ser228 X X X
P37967	P10959	His453 Glu340 Ser221 X X X
P37967	Q869C3	His600 Glu486 Ser360 X X X
P37967	Q8VCU1	His460 Glu347 Ser232 X X X
P37967	Q62765	His525 Glu411 Gly281 X X X
P37967	B0F2B4	His562 Glu396 Gly263 X X X
P37967	Q9NZ94	His523 Glu409 Gly288 X X X
P37967	P0C6R3	His465 Glu353 Ser221 X X X
P37967	Q8BK48	His457 Glu345 Ser228 X X X
P37967	Q8VCT4	His466 Glu353 Ser221 X X X
P37967	P06276	His466 Glu353 Ser226 X X X
P37967	P18167	His466 Asp337 Ser206 X X X
P37967	Q63108	His466 Glu353 Ser221 X X X
P37967	Q8VCC2	His466 Glu353 Ser221 X X X
P37967	Q29499	His448 Glu335 Ser204 X X X
P37967	P07882	His455 Asp340 Ser214 X X X
P37967	Q07085	His446 Glu331 Ser208 X X X
P37967	Q62889	His523 Glu409 Gly288 X X X
P37967	P25726	His467 Asp338 Ser207 X X X
P37967	Q63010	His466 Glu353 Ser221 X X X
P37967	Q3T930	His336 Glu227 Ser108 X X X
P37967	Q03311	His467 Glu354 Ser227 X X X
P37967	Q64285	His455 Asp340 Ser214 X X X
P37967	Q9XTG1	Ser490 Pro370 Gly233 X X X
P37967	Q47M62	His415 Glu319 Ser185 X X X
P37967	Q5UR02	His451 Glu337 Ser217 X X X
P37967	O08710	His2618 Asp2513 Arg2385 X X X
P37967	P18142	His440 Glu338 Ser213 X X X
P37967	P25725	His467 Asp338 Ser207 X X X
P37967	P32750	not aligned not aligned Ser131 X X X
P37967	P32751	not aligned not aligned Ser131 X X X
P37967	P06882	His2620 Asp2515 Arg2387 X X X
P37967	P21837	His443 Glu340 Ser215 X X X
P37967	Q9UKY3	not aligned not aligned Ser222 X X X
P37967	P01266	His2619 Asp2514 Arg2386 X X X
P37967	P32753	not aligned not aligned Ser131 X X X
P37967	D4B1N9	His480 Glu367 Ser235 X X X
P37967	D4ASH1	His448 Asp345 Ser215 X X X
P37967	P32752	not aligned not aligned Ser131 X X X
P37967	A1CFK9	His472 Glu380 Ser258 X X X
P37967	A0A075TXZ3	His477 Glu385 Ser263 X X X
P37967	O94493	His456 Glu346 Ser216 X X X
P37967	D4AZ78	His401 Glu314 Ser196 X X X
P37967	Q96VC9	His409 Glu313 Ser200 X X X
P37967	Q99156	His392 Asp303 Ser193 X X X
P37967	Q64419	His459 Glu345 Ser227 X X X
P37967	P08171	His466 Asp340 Ser209 X X X
P37967	P20261	His464 Glu356 Ser224 X X X
P37967	P32946	His463 Glu355 Ser223 X X X
P37967	P32947	His464 Glu356 Ser224 X X X
P37967	Q92035	His471 Glu358 Ser231 X X X
P37967	P35502	His463 Glu339 Ser214 X X X
P37967	D2D3B6	His448 Glu356 Ser240 X X X
P37967	P12992	His465 Glu351 Ser220 X X X
P37967	P47982	His464 Asp338 Ser207 X X X
P37967	O42275	His494 Glu352 Ser225 X X X
P37967	P17573	His482 Glu373 Ser236 X X X
P37967	Q867X2	not aligned not aligned not aligned X X X
P37967	O16168	His470 Asp341 Ser210 X X X
P37967	Q86GC8	His567 Glu453 Ser327 X X X
P37967	P86325	His415 Glu319 Ser185 X X X
P37967	P32948	His464 Glu356 Ser224 X X X
P37967	O62761	His466 Glu353 Ser226 X X X
P37967	O46421	His467 Glu354 Ser221 X X X
P37967	Q08662	His464 Asp338 Ser207 X X X
P37967	Q92081	not aligned Glu226 Ser99 X X X
P37967	Q05487	Met462 Asn335 Ser204 X X X
P37967	P07692	His464 Glu351 Ser224 X X X
P37967	Q95000	His357 Glu244 Ser112 X X X
P37967	P81429	not aligned not aligned not aligned X X X
P37967	P33438	Leu504 Ala383 Ala246 X X X
P37967	Q86GC9	not aligned not aligned not aligned X X X
P37967	Q95001	not aligned Glu224 Ser99 X X X
P37967	Q01470	His402 Glu307 Ser188 X X X
P37967	P35501	His463 Glu339 Ser214 X X X
P37967	O16173	His470 Asp341 Ser210 X X X
P37967	W4VSJ0	His471 Glu354 Ser223 X X X
P37967	P16854	His442 Glu324 Ser191 X X X
P37967	Q867X3	not aligned not aligned not aligned X X X
P37967	O16169	His467 Asp338 Ser207 X X X
P37967	P23654	not aligned Glu679 Arg548 X X X
P37967	P32949	His464 Glu356 Ser224 X X X
P37967	O16171	His467 Asp338 Ser207 X X X
P37967	O16170	His467 Asp338 Ser207 X X X
P37967	O16172	His467 Asp338 Ser207 X X X
P37967	Q27677	His496 Glu382 Ser253 X X X