Nicotinamidase (M-CSA:716)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of O58727

Reference Sequence Homologue Asp52 His54 Ser60 His71 Glu101 Cys133 (main-N) Lys94 Ala129 (main-N) Cys133 Asp10
O58727
FunTreePfam
O58727
FunTreePfam
Asp52 His54 Ser60 His71 Glu101 Cys133 Lys94 Ala129 Cys133 Asp10
O58727
FunTreePfam
Q93Z51
FunTreePfam
Arg57 His59 not aligned Pro81 Thr108 Cys140 Lys107 Gln136 Cys140 Asp14
O58727
FunTreePfam
I6XD65
FunTreePfam
Asp49 His51 not aligned His71 not aligned Cys138 Lys96 Ala134 Cys138 Asp8
O58727
FunTreePfam
P21369
FunTreePfam
Asp52 His54 Ser60 His86 Asp118 Cys156 Lys111 Ala152 Cys156 Asp10
O58727
FunTreePfam
Q9USS0
FunTreePfam
Asp53 His55 Ser61 His94 Glu126 Cys163 Lys119 Ala159 Cys163 Asp11
O58727
FunTreePfam
P53184
FunTreePfam
Asp51 His53 Ser59 His94 Glu129 Cys167 Lys122 Ala163 Cys167 Asp8