M-CSA Mechanism and Catalytic Site Atlas

Adenylate cyclase (M-CSA:58)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P30803, P26769

Reference Sequence	Homologue	Asp477 Asp521 Arg1029 Lys1065 Ile478 (main-C)
P30803	Q23310	Ala454 not aligned Arg1003 Lys1041 not aligned
P30803	Q23681	Asp465 not aligned Arg1019 Lys1058 not aligned
P30803	Q23682	Asp466 not aligned Arg1016 Lys1055 not aligned
P30803	Q29450	Asp284 Asp328 Arg1019 Lys1055 Ile285
P30803	Q3UWA6	not aligned not aligned Arg951 Lys989 not aligned
P30803	X5M8U1	Ala459 not aligned Arg1010 Lys1048 not aligned
P26769	P30804	Asp382 Asp426 Arg1113 Lys1149 Ile383
P26769	P32870	Asp280 Asp324 Arg1105 Lys1141 Ile281
P26769	Q9VK50	Asp304 Asp348 Arg1025 Lys1061 Val305
P26769	Q9VP76	Asp580 Asp624 Arg1528 Lys1564 Ile581
P26769	Q9VW60	Asp322 Asp366 Arg1253 Lys1289 Ile323
P26769	P26769	Asp294 Asp338 Arg1029 Lys1065 Ile295
P26769	A0A078BQP2	Asp390 not aligned Arg949 Lys987 not aligned
P26769	A8WPG9	Asp463 not aligned Arg1023 Lys1062 not aligned
P26769	A8XQC7	Thr496 not aligned Arg1045 Lys1084 not aligned
P26769	B1Q257	not aligned not aligned Arg987 Lys1024 not aligned
P26769	E7EAU8	Ala451 not aligned Arg1026 Lys1064 not aligned
P26769	G5EEE9	Asp443 not aligned Arg1006 Lys1044 not aligned
P26769	G5EFQ0	Asp483 not aligned Arg1046 Lys1084 not aligned
P26769	H2L002	Asp468 not aligned Arg1024 Lys1061 not aligned
P26769	N1NVB7	Asp466 not aligned Arg1022 Lys1059 not aligned
P26769	O02298	not aligned not aligned Lys550 Arg588 His230
P26769	O02740	Ala448 not aligned Arg1012 Lys1050 not aligned
P26769	O16544	Ser486 not aligned Arg1035 Lys1074 not aligned
P26769	O16715	Asp359 not aligned Arg968 Lys1005 not aligned
P26769	O19179	Ser449 not aligned Arg1012 Lys1050 not aligned
P26769	O43306	Asp384 Asp428 Arg1116 Lys1152 Ile385
P26769	O54865	not aligned not aligned Arg552 Lys593 not aligned
P26769	O60266	Asp324 Asp368 Arg1073 Lys1109 Ile325
P26769	O60503	Asp399 Asp443 Arg1196 Lys1232 Ile400
P26769	O62026	Ser408 not aligned Val969 Val1007 not aligned
P26769	O62179	Ser455 not aligned Arg1004 Lys1042 not aligned
P26769	O75343	not aligned not aligned Arg517 Lys553 His199
P26769	O88444	Asp307 Asp351 Arg1007 Lys1043 Ile308
P26769	O95622	Asp474 Asp518 Arg1208 Lys1244 Ile475
P26769	P0A4Y1	not aligned not aligned Arg376 Lys411 not aligned
P26769	P16065	Asp493 not aligned Arg1042 Asn1079 not aligned
P26769	P16066	Asp451 not aligned Arg1004 Lys1041 not aligned
P26769	P16067	Asp435 not aligned Arg989 Lys1026 not aligned
P26769	P16068	not aligned not aligned Arg552 Lys593 not aligned
P26769	P18293	Asp447 not aligned Arg1000 Lys1037 not aligned
P26769	P18910	Asp447 not aligned Arg1000 Lys1037 not aligned
P26769	P19686	not aligned not aligned Lys605 Pro642 not aligned
P26769	P19687	not aligned not aligned Lys607 Pro644 not aligned
P26769	P19754	Asp310 Asp354 Arg1011 Lys1047 Ile311
P26769	P20594	Asp435 not aligned Arg989 Lys1026 not aligned
P26769	P20595	not aligned not aligned Arg552 Lys593 not aligned
P26769	P21932	Asp324 Asp368 Arg1073 Lys1109 Ile325
P26769	P22717	not aligned not aligned Arg534 Lys570 His216
P26769	P23897	not aligned not aligned Arg951 Lys989 not aligned
P26769	P25092	not aligned not aligned Arg952 Lys990 not aligned
P26769	P26770	Asp278 Asp322 Arg1005 Lys1041 Ile279
P26769	P30803	Asp477 Asp521 Arg1212 Lys1248 Ile478
P26769	P33402	not aligned not aligned Lys646 Pro683 not aligned
P26769	P40137	X X Arg361 Pro398 X
P26769	P40144	Asp477 Asp521 Arg1211 Lys1247 Ile478
P26769	P40145	Asp419 Asp463 Arg1120 Lys1156 Val420
P26769	P40146	Asp416 Asp460 Arg1117 Lys1153 Val417
P26769	P46197	Asp435 not aligned Arg989 Lys1026 not aligned
P26769	P51828	Asp284 Asp328 Arg1021 Lys1057 Ile285
P26769	P51829	Asp286 Asp330 Arg1040 Lys1076 Ile287
P26769	P51830	Asp399 Asp443 Arg1196 Lys1232 Ile400
P26769	P51839	His458 not aligned Arg1021 Lys1059 not aligned
P26769	P51840	Pro448 not aligned Arg1011 Lys1049 not aligned
P26769	P51841	Ala448 not aligned Arg1012 Lys1050 not aligned
P26769	P51842	Ala448 not aligned Arg1012 Lys1050 not aligned
P26769	P52785	Pro448 not aligned Arg1011 Lys1049 not aligned
P26769	P55202	Asp439 not aligned Arg993 Lys1030 not aligned
P26769	P55203	Pro450 not aligned Ala1013 Lys1051 not aligned
P26769	P55204	not aligned not aligned Arg952 Lys990 not aligned
P26769	P55205	Tyr454 not aligned Arg1029 Lys1066 not aligned
P26769	P70106	not aligned not aligned Arg955 Lys993 not aligned
P26769	P84309	Asp475 Asp519 Arg1209 Lys1245 Ile476
P26769	P90895	not aligned Gly70 Arg565 Lys605 not aligned
P26769	P91550	Asp413 not aligned Arg1022 Lys1070 not aligned
P26769	P92006	not aligned not aligned Gln581 Lys618 not aligned
P26769	P97490	Asp417 Asp461 Arg1118 Lys1154 Val418
P26769	P98999	Asp393 Asp437 Arg1187 Lys1223 Ile394
P26769	P9WQ34	not aligned not aligned Arg376 Lys411 not aligned
P26769	P9WQ35	not aligned not aligned Arg376 Lys411 not aligned
P26769	Q01341	Asp382 Asp426 Arg1113 Lys1149 Ile383
P26769	Q02108	not aligned not aligned Lys606 Pro643 not aligned
P26769	Q02153	not aligned not aligned Arg552 Lys593 not aligned
P26769	Q02846	Pro445 not aligned Arg1008 Lys1046 not aligned
P26769	Q03100	Asp443 Asp488 Arg1309 Lys1344 Ile444
P26769	Q03101	not aligned not aligned Arg524 Lys560 not aligned
P26769	Q03343	Asp382 Asp426 Arg1114 Lys1150 Ile383
P26769	Q04400	Asp475 Asp519 Arg1209 Lys1245 Ile476
P26769	Q07093	not aligned not aligned Lys591 Pro630 not aligned
P26769	Q07553	Ala450 not aligned Arg1001 Lys1038 not aligned
P26769	Q08462	Asp295 Asp339 Arg1030 Lys1066 Ile296
P26769	Q08828	Asp308 Asp352 Arg1008 Lys1044 Ile309
P26769	Q09435	Asp474 not aligned Arg1026 Lys1065 not aligned
P26769	Q10028	Ala475 not aligned Arg1025 Lys1064 not aligned
P26769	Q10029	Asp475 not aligned Arg1000 Lys1039 not aligned
P26769	Q18331	Ser538 not aligned Met1124 Lys1161 not aligned
P26769	Q19187	Asp578 not aligned Arg1156 Lys1194 not aligned
P26769	Q19768	Thr416 not aligned Arg972 Lys1010 not aligned
P26769	Q23310	Ala454 not aligned Arg1003 Lys1041 not aligned
P26769	Q23681	Asp465 not aligned Arg1019 Lys1058 not aligned
P26769	Q23682	Asp466 not aligned Arg1016 Lys1055 not aligned
P26769	Q29450	Asp284 Asp328 Arg1019 Lys1055 Ile285
P26769	Q3UWA6	not aligned not aligned Arg951 Lys989 not aligned
P26769	Q4ZHR9	not aligned not aligned Arg552 Lys593 not aligned
P26769	Q4ZHS0	not aligned not aligned Lys606 Pro643 not aligned
P26769	Q553Y7	not aligned not aligned Gln1294 Lys1330 Ile204
P26769	Q5SDA5	Ala448 not aligned Arg1012 Lys1050 not aligned
P26769	Q6DNF3	not aligned not aligned Ser560 Gln599 not aligned
P26769	Q6DNF4	not aligned not aligned Arg576 Lys613 not aligned
P26769	Q6DNF7	not aligned not aligned Gln580 Lys617 not aligned
P26769	Q6TL19	Tyr454 not aligned Arg1029 Lys1066 not aligned
P26769	Q6VVW5	Asp435 not aligned Arg989 Lys1026 not aligned
P26769	Q7JQ32	Asp472 not aligned Arg1024 Lys1062 not aligned
P26769	Q80TL1	Asp294 Asp338 Arg1029 Lys1065 Ile295
P26769	Q86C56	not aligned not aligned Lys562 Lys601 not aligned
P26769	Q86GV3	Asp498 not aligned Arg1213 Lys1250 not aligned
P26769	Q8I4N4	Asp321 not aligned Lys893 Glu931 not aligned
P26769	Q8INF0	not aligned not aligned Arg547 Lys582 Cys215
P26769	Q8NFM4	Asp278 Asp322 Arg1016 Lys1052 Ile279
P26769	Q8VHH7	Asp324 Asp368 Arg1074 Lys1110 Ile325
P26769	Q91WF3	Asp278 Asp322 Arg1018 Lys1054 Ile279
P26769	Q9DGG6	Asp388 Asp432 Arg1178 Lys1214 Ile389
P26769	Q9ERL9	not aligned not aligned Lys606 Pro643 not aligned
P26769	Q9GYQ4	Asp492 not aligned Arg1055 Lys1093 not aligned
P26769	Q9VEU5	not aligned not aligned Arg618 Lys654 not aligned
P26769	Q9VEU6	not aligned not aligned Arg615 Lys651 not aligned
P26769	Q9WVI4	not aligned not aligned Lys644 Pro681 not aligned
P26769	Q9XTY1	Ser449 not aligned Arg995 Lys1033 not aligned
P26769	Q9XU42	not aligned not aligned Arg666 Lys703 not aligned
P26769	X5M8U1	Ala459 not aligned Arg1010 Lys1048 not aligned
P30803	P30803	Asp477 Asp521 Arg1212 Lys1248 Ile478
P30803	A0A078BQP2	Asp390 not aligned Arg949 Lys987 not aligned
P30803	A8WPG9	Asp463 not aligned Arg1023 Lys1062 not aligned
P30803	A8XQC7	Thr496 not aligned Arg1045 Lys1084 not aligned
P30803	B1Q257	not aligned not aligned Arg987 Lys1024 not aligned
P30803	E7EAU8	Ala451 not aligned Arg1026 Lys1064 not aligned
P30803	G5EEE9	Asp443 not aligned Arg1006 Lys1044 not aligned
P30803	G5EFQ0	Asp483 not aligned Arg1046 Lys1084 not aligned
P30803	H2L002	Asp468 not aligned Arg1024 Lys1061 not aligned
P30803	N1NVB7	Asp466 not aligned Arg1022 Lys1059 not aligned
P30803	O02298	not aligned not aligned Lys550 Arg588 His230
P30803	O02740	Ala448 not aligned Arg1012 Lys1050 not aligned
P30803	O16544	Ser486 not aligned Arg1035 Lys1074 not aligned
P30803	O16715	Asp359 not aligned Arg968 Lys1005 not aligned
P30803	O19179	Ser449 not aligned Arg1012 Lys1050 not aligned
P30803	O43306	Asp384 Asp428 Arg1116 Lys1152 Ile385
P30803	O54865	not aligned not aligned Arg552 Lys593 not aligned
P30803	O60266	Asp324 Asp368 Arg1073 Lys1109 Ile325
P30803	O60503	Asp399 Asp443 Arg1196 Lys1232 Ile400
P30803	O62026	Ser408 not aligned Val969 Val1007 not aligned
P30803	O62179	Ser455 not aligned Arg1004 Lys1042 not aligned
P30803	O75343	not aligned not aligned Arg517 Lys553 His199
P30803	O88444	Asp307 Asp351 Arg1007 Lys1043 Ile308
P30803	O95622	Asp474 Asp518 Arg1208 Lys1244 Ile475
P30803	P0A4Y1	not aligned not aligned Arg376 Lys411 not aligned
P30803	P16065	Asp493 not aligned Arg1042 Asn1079 not aligned
P30803	P16066	Asp451 not aligned Arg1004 Lys1041 not aligned
P30803	P16067	Asp435 not aligned Arg989 Lys1026 not aligned
P30803	P16068	not aligned not aligned Arg552 Lys593 not aligned
P30803	P18293	Asp447 not aligned Arg1000 Lys1037 not aligned
P30803	P18910	Asp447 not aligned Arg1000 Lys1037 not aligned
P30803	P19686	not aligned not aligned Lys605 Pro642 not aligned
P30803	P19687	not aligned not aligned Lys607 Pro644 not aligned
P30803	P19754	Asp310 Asp354 Arg1011 Lys1047 Ile311
P30803	P20594	Asp435 not aligned Arg989 Lys1026 not aligned
P30803	P20595	not aligned not aligned Arg552 Lys593 not aligned
P30803	P21932	Asp324 Asp368 Arg1073 Lys1109 Ile325
P30803	P22717	not aligned not aligned Arg534 Lys570 His216
P30803	P23897	not aligned not aligned Arg951 Lys989 not aligned
P30803	P25092	not aligned not aligned Arg952 Lys990 not aligned
P30803	P26769	Asp294 Asp338 Arg1029 Lys1065 Ile295
P30803	P26770	Asp278 Asp322 Arg1005 Lys1041 Ile279
P30803	P30804	Asp382 Asp426 Arg1113 Lys1149 Ile383
P30803	P32870	Asp280 Asp324 Arg1105 Lys1141 Ile281
P30803	P9WQ35	not aligned not aligned Arg376 Lys411 not aligned
P30803	Q01341	Asp382 Asp426 Arg1113 Lys1149 Ile383
P30803	P33402	not aligned not aligned Lys646 Pro683 not aligned
P30803	P40144	Asp477 Asp521 Arg1211 Lys1247 Ile478
P30803	P40145	Asp419 Asp463 Arg1120 Lys1156 Val420
P30803	P40146	Asp416 Asp460 Arg1117 Lys1153 Val417
P30803	P46197	Asp435 not aligned Arg989 Lys1026 not aligned
P30803	P51828	Asp284 Asp328 Arg1021 Lys1057 Ile285
P30803	P51829	Asp286 Asp330 Arg1040 Lys1076 Ile287
P30803	P51830	Asp399 Asp443 Arg1196 Lys1232 Ile400
P30803	P51839	His458 not aligned Arg1021 Lys1059 not aligned
P30803	P51840	Pro448 not aligned Arg1011 Lys1049 not aligned
P30803	P51841	Ala448 not aligned Arg1012 Lys1050 not aligned
P30803	P51842	Ala448 not aligned Arg1012 Lys1050 not aligned
P30803	P52785	Pro448 not aligned Arg1011 Lys1049 not aligned
P30803	P55202	Asp439 not aligned Arg993 Lys1030 not aligned
P30803	P55203	Pro450 not aligned Ala1013 Lys1051 not aligned
P30803	P55204	not aligned not aligned Arg952 Lys990 not aligned
P30803	P55205	Tyr454 not aligned Arg1029 Lys1066 not aligned
P30803	P70106	not aligned not aligned Arg955 Lys993 not aligned
P30803	P84309	Asp475 Asp519 Arg1209 Lys1245 Ile476
P30803	P90895	not aligned Gly70 Arg565 Lys605 not aligned
P30803	P91550	Asp413 not aligned Arg1022 Lys1070 not aligned
P30803	P92006	not aligned not aligned Gln581 Lys618 not aligned
P30803	P97490	Asp417 Asp461 Arg1118 Lys1154 Val418
P30803	P98999	Asp393 Asp437 Arg1187 Lys1223 Ile394
P30803	P9WQ34	not aligned not aligned Arg376 Lys411 not aligned
P30803	Q08462	Asp295 Asp339 Arg1030 Lys1066 Ile296
P30803	Q08828	Asp308 Asp352 Arg1008 Lys1044 Ile309
P30803	Q09435	Asp474 not aligned Arg1026 Lys1065 not aligned
P30803	Q10028	Ala475 not aligned Arg1025 Lys1064 not aligned
P30803	Q10029	Asp475 not aligned Arg1000 Lys1039 not aligned
P30803	Q18331	Ser538 not aligned Met1124 Lys1161 not aligned
P30803	Q19187	Asp578 not aligned Arg1156 Lys1194 not aligned
P30803	Q19768	Thr416 not aligned Arg972 Lys1010 not aligned
P30803	Q02108	not aligned not aligned Lys606 Pro643 not aligned
P30803	Q02153	not aligned not aligned Arg552 Lys593 not aligned
P30803	Q02846	Pro445 not aligned Arg1008 Lys1046 not aligned
P30803	Q03100	Asp443 Asp488 Arg1309 Lys1344 Ile444
P30803	Q03101	not aligned not aligned Arg524 Lys560 not aligned
P30803	Q03343	Asp382 Asp426 Arg1114 Lys1150 Ile383
P30803	Q04400	Asp475 Asp519 Arg1209 Lys1245 Ile476
P30803	Q07093	not aligned not aligned Lys591 Pro630 not aligned
P30803	Q07553	Ala450 not aligned Arg1001 Lys1038 not aligned
P30803	Q4ZHR9	not aligned not aligned Arg552 Lys593 not aligned
P30803	Q4ZHS0	not aligned not aligned Lys606 Pro643 not aligned
P30803	Q553Y7	not aligned not aligned Gln1294 Lys1330 Ile204
P30803	Q5SDA5	Ala448 not aligned Arg1012 Lys1050 not aligned
P30803	Q6DNF3	not aligned not aligned Ser560 Gln599 not aligned
P30803	Q6DNF4	not aligned not aligned Arg576 Lys613 not aligned
P30803	Q6DNF7	not aligned not aligned Gln580 Lys617 not aligned
P30803	Q6TL19	Tyr454 not aligned Arg1029 Lys1066 not aligned
P30803	Q6VVW5	Asp435 not aligned Arg989 Lys1026 not aligned
P30803	Q7JQ32	Asp472 not aligned Arg1024 Lys1062 not aligned
P30803	Q80TL1	Asp294 Asp338 Arg1029 Lys1065 Ile295
P30803	Q86C56	not aligned not aligned Lys562 Lys601 not aligned
P30803	Q86GV3	Asp498 not aligned Arg1213 Lys1250 not aligned
P30803	Q8I4N4	Asp321 not aligned Lys893 Glu931 not aligned
P30803	Q8INF0	not aligned not aligned Arg547 Lys582 Cys215
P30803	Q8NFM4	Asp278 Asp322 Arg1016 Lys1052 Ile279
P30803	Q8VHH7	Asp324 Asp368 Arg1074 Lys1110 Ile325
P30803	Q91WF3	Asp278 Asp322 Arg1018 Lys1054 Ile279
P30803	Q9DGG6	Asp388 Asp432 Arg1178 Lys1214 Ile389
P30803	Q9ERL9	not aligned not aligned Lys606 Pro643 not aligned
P30803	Q9GYQ4	Asp492 not aligned Arg1055 Lys1093 not aligned
P30803	Q9VEU5	not aligned not aligned Arg618 Lys654 not aligned
P30803	Q9VEU6	not aligned not aligned Arg615 Lys651 not aligned
P30803	Q9VK50	Asp304 Asp348 Arg1025 Lys1061 Val305
P30803	Q9VP76	Asp580 Asp624 Arg1528 Lys1564 Ile581
P30803	Q9VW60	Asp322 Asp366 Arg1253 Lys1289 Ile323
P30803	Q9WVI4	not aligned not aligned Lys644 Pro681 not aligned
P30803	Q9XTY1	Ser449 not aligned Arg995 Lys1033 not aligned
P30803	Q9XU42	not aligned not aligned Arg666 Lys703 not aligned