M-CSA Mechanism and Catalytic Site Atlas

Formate dehydrogenase (nitrate-inducible) (M-CSA:563)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P0AEK7, P24183

Reference Sequence	Homologue	Sec196 His197 His169
P0AEK7	P0AEK7	X X His169
P0AEK7	P0AEK8	X X His169
P0AEK7	P0AEK9	X X His169
P0AEK7	P0AEL0	X X His167
P0AEK7	P0AEL1	X X His167
P0AEK7	P0AEL2	X X His167
P0AEK7	P44451	X X His174
P24183	P24183	Sec196 His197 X
P24183	A0KIM1	Cys181 Met182 X
P24183	A0RQ36	Cys177 Met178 X
P24183	C0SP82	Cys146 Ser147 X
P24183	P61159	Sec131 His132 X
P24183	A1AD59	Cys179 Met180 X
P24183	A1JL26	Cys180 Met181 X
P24183	A1SWQ0	Cys181 Met182 X
P24183	A1VZC8	Cys175 Met176 X
P24183	A3N277	Cys177 Met178 X
P24183	A4SPG7	Cys181 Met182 X
P24183	A4TMK8	Cys179 Met180 X
P24183	A4VJ11	Cys181 Met182 X
P24183	A4XWM0	Cys181 Met182 X
P24183	A4Z0A1	Cys184 Met185 X
P24183	A5ED21	Cys184 Met185 X
P24183	A5EZX9	Cys181 Met182 X
P24183	A5UAE1	Cys177 Met178 X
P24183	A6Q604	Cys181 Met182 X
P24183	A6V924	Cys181 Met182 X
P24183	A6VQY7	Cys177 Met178 X
P24183	A7FG75	Cys179 Met180 X
P24183	A7GZP5	Cys178 Met179 X
P24183	A7I3Y7	Cys176 Met177 X
P24183	A7N7J3	Cys181 Met182 X
P24183	A7ZCK4	Cys178 Met179 X
P24183	A7ZP28	Cys179 Met180 X
P24183	A8A268	Cys179 Met180 X
P24183	A8AE11	Cys179 Met180 X
P24183	A8FLJ3	Cys176 Met177 X
P24183	A8GHJ4	Cys179 Met180 X
P24183	A8LLY9	Cys182 Met183 X
P24183	A9I7M5	Cys180 Met181 X
P24183	A9MJZ6	Cys179 Met180 X
P24183	A9N5G2	Cys179 Met180 X
P24183	A9QZL3	Cys179 Met180 X
P24183	B0BR28	Cys177 Met178 X
P24183	B0TSW5	Cys179 Met180 X
P24183	B0UCB6	Cys180 Met181 X
P24183	B0URQ3	Cys177 Met178 X
P24183	B1IY66	Cys179 Met180 X
P24183	B1JSJ0	Cys179 Met180 X
P24183	B1LKV2	Cys179 Met180 X
P24183	B1X8A2	Cys179 Met180 X
P24183	B1Y6A6	Cys184 Met185 X
P24183	B2K970	Cys179 Met180 X
P24183	B2TV30	Cys179 Met180 X
P24183	B2UBL7	Cys181 Met182 X
P24183	B3H2D1	Cys177 Met178 X
P24183	B3R8B4	Cys181 Met182 X
P24183	B4SYT3	Cys179 Met180 X
P24183	B4TAT3	Cys179 Met180 X
P24183	B4TPE6	Cys179 Met180 X
P24183	B5BDZ4	Cys179 Met180 X
P24183	B5EYU5	Cys179 Met180 X
P24183	B5FGW1	Cys181 Met182 X
P24183	B5FNQ2	Cys179 Met180 X
P24183	B5R233	Cys179 Met180 X
P24183	B5RC85	Cys179 Met180 X
P24183	B5YWZ7	Cys179 Met180 X
P24183	B6I1A4	Cys179 Met180 X
P24183	B7LAM9	Cys179 Met180 X
P24183	B7LJU7	Cys179 Met180 X
P24183	B7M5P6	Cys179 Met180 X
P24183	B7MFB8	Cys179 Met180 X
P24183	B7MXN6	Cys179 Met180 X
P24183	B7N5G7	Cys179 Met180 X
P24183	B7NN18	Cys179 Met180 X
P24183	B7UFL9	Cys179 Met180 X
P24183	B7UX15	Cys181 Met182 X
P24183	B7VRL0	Cys181 Met182 X
P24183	B8F7K2	Cys177 Met178 X
P24183	B9KCQ2	Cys176 Met177 X
P24183	B9L8L4	Cys181 Met182 X
P24183	C0Q0P2	Cys179 Met180 X
P24183	C1D9G3	Cys186 Met187 X
P24183	C3LVU3	Cys181 Met182 X
P24183	C4ZU48	Cys179 Met180 X
P24183	C5B7B9	Cys180 Met181 X
P24183	C6DK59	Cys179 Met180 X
P24183	D3RNN8	Cys149 Ser150 X
P24183	I3R634	Cys148 Met149 X
P24183	O33732	Cys138 Met139 X
P24183	O34720	Cys391 Gln392 X
P24183	P06131	Cys132 His133 X
P24183	P07658	Sec140 His141 X
P24183	P18775	Ser205 Ser206 X
P24183	P32176	Sec196 His197 X
P24183	P33937	Cys179 Met180 X
P24183	P37519	Cys134 Trp135 X
P24183	P39185	Cys181 Met182 X
P24183	P39458	Cys162 Met163 X
P24183	P42434	Cys154 Met155 X
P24183	P45004	Ser196 Thr197 X
P24183	P46448	Sec204 His205 X
P24183	P65409	Cys206 His207 X
P24183	P73448	Cys148 Met149 X
P24183	P77374	Ser196 Thr197 X
P24183	P77561	Cys182 His183 X
P24183	P77783	Ser195 Thr196 X
P24183	P81186	Cys172 Met173 X
P24183	P9WJP8	Cys206 His207 X
P24183	P9WJP9	Cys206 His207 X
P24183	Q02IZ4	Cys181 Met182 X
P24183	Q06457	Cys130 Met131 X
P24183	Q0I5G9	Cys177 Met178 X
P24183	Q0T2R8	Cys179 Met180 X
P24183	Q0TFN6	Cys179 Met180 X
P24183	Q12P44	Cys179 Met180 X
P24183	Q13I15	Cys177 Met178 X
P24183	Q1C5S8	Cys179 Met180 X
P24183	Q1CK03	Cys179 Met180 X
P24183	Q1R9L3	Cys179 Met180 X
P24183	Q21AR4	Cys184 Met185 X
P24183	Q21PN1	Cys181 Met182 X
P24183	Q2FEI5	Cys390 Gln391 X
P24183	Q2FVV9	Cys390 Gln391 X
P24183	Q2SGV7	Cys180 Met181 X
P24183	Q2W3T1	Cys177 Met178 X
P24183	Q46RX3	Cys181 Met182 X
P24183	Q2YYT1	Cys390 Gln391 X
P24183	Q31Z29	Cys179 Met180 X
P24183	Q32I06	Cys179 Met180 X
P24183	Q3HS05	Cys181 Met182 X
P24183	Q3Z001	Cys179 Met180 X
P24183	Q47A87	Cys177 Met178 X
P24183	Q487G4	Cys181 Met182 X
P24183	Q49ZN0	Cys390 Gln391 X
P24183	Q4L8G8	Cys390 Gln391 X
P24183	Q4QNJ6	Cys177 Met178 X
P24183	Q53176	Cys181 Met182 X
P24183	Q56350	Cys181 Met182 X
P24183	Q57M92	Cys179 Met180 X
P24183	Q5E3J6	Cys181 Met182 X
P24183	Q5HDP9	Cys390 Gln391 X
P24183	Q5HV12	Cys176 Met177 X
P24183	Q5PI61	Cys179 Met180 X
P24183	Q65Q72	Cys180 Met181 X
P24183	Q668I0	Cys179 Met180 X
P24183	Q67QZ1	Cys173 Met174 X
P24183	Q6D5Z2	Cys179 Met180 X
P24183	Q6G711	Cys390 Gln391 X
P24183	Q6GEC4	Cys390 Gln391 X
P24183	Q6LQJ3	Cys181 Met182 X
P24183	Q6LTV9	Cys181 Met182 X
P24183	Q727P3	Sec189 His190 X
P24183	Q795Y4	Cys396 Gln397 X
P24183	Q7A057	Cys390 Gln391 X
P24183	Q7WIQ1	Cys179 Met180 X
P24183	Q7M962	Cys181 Met182 X
P24183	Q7MD44	Cys181 Met182 X
P24183	Q7VJT5	Cys195 Met196 X
P24183	Q7VPJ7	Cys177 Met178 X
P24183	Q7W733	Cys181 Met182 X
P24183	Q83QV0	Cys179 Met180 X
P24183	Q83RF3	Cys182 His183 X
P24183	Q87GW6	Cys181 Met182 X
P24183	Q89EN5	Cys184 Met185 X
P24183	Q8CVW4	Cys179 Met180 X
P24183	Q8D623	Cys181 Met182 X
P24183	Q8EIJ1	Cys178 Met179 X
P24183	Q8FHF8	Cys182 His183 X
P24183	Q8GPG4	not aligned not aligned X
P24183	Q8U7P1	Cys183 Met184 X
P24183	Q8VL02	Cys177 Met178 X
P24183	Q8XAX1	Cys182 His183 X
P24183	Q8XE47	Cys179 Met180 X
P24183	Q8Z570	Cys179 Met180 X
P24183	Q8ZCF3	Cys179 Met180 X
P24183	Q8ZNH6	Cys179 Met180 X
P24183	Q92Z36	Cys183 Met184 X
P24183	Q931G2	Cys390 Gln391 X
P24183	Q934F5	Sec193 His194 X
P24183	Q93HX3	Cys177 Met178 X
P24183	Q99RW4	Cys390 Gln391 X
P24183	Q9CKL8	Cys178 Met179 X
P24183	Q9I4G3	Cys176 Met177 X
P24183	Q9KLR4	Cys181 Met182 X
P24183	Q9PPD9	Cys176 Met177 X