M-CSA Mechanism and Catalytic Site Atlas

Histone acetyltransferase (GCN5 family) (M-CSA:524)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of Q92830

Reference Sequence	Homologue	Phe573 Glu575 Val577 Ile576 Leu611 Ile642 Tyr645 Phe568 Cys579 (main-N)
Q92830	Q03330	Phe171 Glu173 Val175 Ile174 Leu210 Ile241 Tyr244 Phe166 Cys177
Q92830	Q92831	Phe568 Glu570 Val572 Ile571 Leu606 Ile637 Tyr640 Phe563 Cys574
Q92830	Q1LUC3	Phe534 Glu536 Val538 Ile537 Leu572 Ile603 Tyr606 Phe529 Cys540
Q92830	Q6BGW1	Phe185 Glu187 Val189 Ile188 Leu224 Ile255 Tyr258 Phe180 Cys191
Q92830	E9Q2Z1	not aligned not aligned not aligned not aligned Ser462 Lys492 not aligned Phe439 not aligned
Q92830	P13709	not aligned not aligned not aligned not aligned Gly84 Val114 not aligned Phe59 not aligned
Q92830	Q15059	not aligned not aligned not aligned not aligned Gly84 Ile114 not aligned Phe59 not aligned
Q92830	Q9Y7N0	not aligned not aligned not aligned not aligned Gly134 Leu164 not aligned Phe109 not aligned
Q92830	P51123	not aligned Glu1060 Val1069 Ile1061 Leu1153 Ile1216 Asn1223 not aligned Asp1071
Q92830	Q756G9	Phe184 Glu186 Val188 Ile187 Leu223 Ile254 Tyr257 Phe179 Cys190
Q92830	Q9UIF9	not aligned Pro1487 not aligned Ile1488 Ala1591 not aligned Tyr1635 not aligned not aligned
Q92830	Q9JHD2	Phe566 Glu568 Val570 Ile569 Leu604 Ile635 Tyr638 Phe561 Cys572
Q92830	Q6CXW4	Phe248 Glu250 Val252 Ile251 Leu287 Ile318 Tyr321 Phe243 Cys254
Q92830	Q92830	Phe573 Glu575 Val577 Ile576 Leu611 Ile642 Tyr645 Phe568 Cys579
Q92830	Q9BXF3	not aligned not aligned not aligned not aligned Ser482 Lys512 not aligned Phe459 not aligned
Q92830	P25440	not aligned not aligned not aligned not aligned Gly124 Ile154 not aligned Phe99 not aligned
Q92830	Q09948	Asn124 Glu126 not aligned Met127 Lys193 Val231 not aligned Tyr99 not aligned
Q92830	Q91Y44	not aligned not aligned not aligned not aligned Asn76 Leu106 not aligned Phe51 not aligned
Q92830	Q7JJ13	not aligned not aligned not aligned not aligned Gly123 Ile153 not aligned Phe98 not aligned
Q92830	P21675	not aligned Glu1016 Val1025 Ile1017 Leu1108 Ile1167 Glu1174 not aligned Asp1027
Q92830	Q12830	Gln2567 Gln2569 not aligned Val2570 Phe2742 not aligned Glu2840 not aligned Ser2572
Q92830	A2BIL7	Tyr1039 Glu1041 Ile1046 Ile1042 Ile1115 Val1151 Gln1154 Val997 Leu1048
Q92830	Q8WZM0	Phe198 Glu200 Val202 Ile201 Leu237 Ile268 Tyr271 Phe193 Cys204
Q92830	D4A7T3	not aligned not aligned not aligned not aligned Ser76 Leu106 not aligned Phe51 not aligned
Q92830	Q84XV2	Val40 Glu42 not aligned Ile43 not aligned not aligned not aligned Phe36 not aligned
Q92830	Q86U86	Ala336 Gln338 Ile345 not aligned Gln431 Ile469 not aligned Phe270 Met347
Q92830	Q6FTW5	Phe278 Glu280 Val282 Ile281 Leu317 Ile348 Tyr351 Phe273 Cys284
Q92830	Q8BSQ9	Ala336 Gln338 Ile345 not aligned Gln431 Ile469 not aligned Phe270 Met347
Q92830	Q8K2F0	not aligned not aligned not aligned not aligned Gly83 Ile113 not aligned Phe58 not aligned
Q92830	O60885	not aligned not aligned not aligned not aligned Gly108 Ile138 not aligned Phe83 not aligned
Q92830	Q07442	not aligned not aligned not aligned not aligned Ser183 Asn213 not aligned Phe158 not aligned
Q92830	Q95Y80	not aligned not aligned not aligned not aligned Lys89 Thr119 not aligned Phe64 not aligned
Q92830	Q80UV9	not aligned Glu1037 Val1046 Ile1038 Leu1129 Ile1188 Glu1195 not aligned Asp1048
Q92830	Q91YE5	not aligned Pro1473 not aligned Ile1474 Ala1577 not aligned Tyr1621 not aligned not aligned
Q92830	Q9AR19	Phe287 Glu289 Ala291 Ile290 Leu326 Ile357 Tyr360 Tyr282 Cys293
Q92830	Q8IZX4	not aligned Glu1035 Val1044 Ile1036 Leu1127 Ile1186 Glu1193 not aligned Asp1046
Q92830	F1QW93	not aligned not aligned not aligned not aligned Thr79 Val109 not aligned Phe54 not aligned
Q92830	Q5TJG6	not aligned not aligned not aligned not aligned Gly124 Ile154 not aligned Phe99 not aligned
Q92830	Q9ESU6	not aligned not aligned not aligned not aligned Gly108 Ile138 not aligned Phe83 not aligned
Q92830	Q90941	Ser334 Gln336 Ile343 not aligned Gln429 Ile467 not aligned Phe267 Met345
Q92830	F7DRV9	not aligned not aligned not aligned not aligned Ser78 Ile108 not aligned Phe53 not aligned
Q92830	Q9JHD1	Phe549 Glu551 Val553 Ile552 Leu587 Ile618 Tyr621 Phe544 Cys555
Q92830	A0A0R4IXF6	Phe531 Glu533 Val535 Ile534 Leu569 Ile600 Tyr603 Phe526 Cys537
Q92830	Q58F21	not aligned not aligned not aligned not aligned Asn77 Leu107 not aligned Phe52 not aligned
Q92830	Q9UUK2	Phe189 Glu191 Val193 Ile192 Leu228 Ile259 Tyr262 Phe184 Cys195
Q92830	Q6MGA9	not aligned not aligned not aligned not aligned Gly123 Ile153 not aligned Phe98 not aligned
Q92830	Q9W0T1	Gln2097 Gln2099 not aligned Leu2100 Glu2354 not aligned not aligned not aligned not aligned
Q92830	Q4R8Y1	not aligned not aligned not aligned not aligned Asn77 Leu107 not aligned Phe52 not aligned
Q92830	Q9HGP4	not aligned not aligned not aligned not aligned Gly279 Leu309 not aligned Phe254 not aligned
Q92830	Q54UW4	not aligned not aligned not aligned not aligned Ser355 Ile385 not aligned Phe332 not aligned
Q92830	Q338B9	Phe231 Glu233 Ala235 Ile234 Leu270 Ile301 Tyr304 Tyr226 Cys237
Q92830	Q32S26	not aligned not aligned not aligned not aligned Gly124 Ile154 not aligned Phe99 not aligned
Q92830	F1R5H6	not aligned not aligned not aligned not aligned Gly93 Ile123 not aligned Phe68 not aligned
Q92830	O88379	Gln976 Glu978 Phe984 Leu979 Phe1086 not aligned Tyr1110 Phe896 Leu986
Q92830	Q9NRL2	Gln974 Glu976 Phe982 Leu977 Phe1085 not aligned Tyr1109 Phe894 Leu984
Q92830	Q60544	not aligned Glu1011 Val1020 Ile1012 Leu1103 Ile1162 Glu1169 not aligned Asp1022
Q92830	Q08D75	not aligned not aligned not aligned not aligned Gly108 Ile138 not aligned Phe83 not aligned
Q92830	Q6DFF2	not aligned not aligned not aligned not aligned Gly107 Ile137 not aligned Phe82 not aligned