M-CSA Mechanism and Catalytic Site Atlas

Galactarate dehydratase (D-threo-forming) (M-CSA:502)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of Q8EMJ9

Reference Sequence	Homologue	Arg162 Tyr164 His246 Asp193 Glu221 Thr297 Asp42 His45 Tyr90
Q8EMJ9	P08310	Lys169 Lys171 Ser253 Asp200 Glu226 Met304 Thr55 Glu67 not aligned
Q8EMJ9	P05404	Lys163 Lys165 Ser247 Asp194 Glu220 Met298 Ser49 Glu61 not aligned
Q8EMJ9	P11452	Lys163 Lys165 Ser247 Asp194 Glu220 Met298 Ser49 Glu61 not aligned
Q8EMJ9	Q8EMJ9	Arg162 Tyr164 His246 Asp193 Glu221 Thr297 Asp42 His45 Tyr90
Q8EMJ9	Q607C7	Lys160 Lys162 Ser243 Asp190 Glu216 Met295 Pro50 Glu60 not aligned
Q8EMJ9	Q834W6	Lys159 Lys161 Ser242 Asp189 Glu215 Met293 Pro50 Ala60 not aligned
Q8EMJ9	Q81IL5	Lys161 Lys163 Gly245 Asp191 Glu218 Met296 Ala50 Glu60 not aligned
Q8EMJ9	Q43931	Lys164 Lys166 Val248 Asp195 Glu221 Met299 Thr49 Glu61 not aligned
Q8EMJ9	O34508	Lys160 Lys162 Ser246 Asp191 Glu219 Met297 Pro50 Asp60 not aligned
Q8EMJ9	Q97MK4	Lys160 Lys162 Ser245 Asp190 Glu218 Met296 Ser50 Glu60 not aligned
Q8EMJ9	D4GP40	Lys184 Asp186 Asn283 Asp230 Glu256 Val334 not aligned Gly73 Glu108
Q8EMJ9	B3PDB1	Arg147 Gln149 Val263 Asp210 Glu236 Ala314 not aligned Lys41 Arg77
Q8EMJ9	Q11T61	Lys160 Lys162 Ser243 Asp190 Glu216 Phe294 Pro50 Asp60 not aligned
Q8EMJ9	A6VRA1	Arg147 Gln149 Val264 Asp211 Glu237 Ala315 not aligned Lys41 Arg77
Q8EMJ9	Q9AAR4	Arg148 Gln150 Ile264 Asp211 Glu237 Ala315 not aligned Leu42 Arg78
Q8EMJ9	Q9A4L8	Arg148 Gln150 Ile264 Asp211 Glu237 Ala315 not aligned Leu42 Arg78
Q8EMJ9	B8HCK2	Arg147 Gln149 Ile270 Asp217 Glu243 Pro321 not aligned Leu41 Arg77
Q8EMJ9	D7BPX0	Arg155 Gln157 Val272 Asp219 Glu245 Pro323 not aligned Leu49 Arg85
Q8EMJ9	C6CVY9	Arg149 Gln151 Leu261 Asp208 Glu234 Gly312 not aligned Glu43 Arg79
Q8EMJ9	B0TZW0	Lys161 Lys163 Ser246 Asp191 Glu219 Met297 Ala51 Gln61 not aligned
Q8EMJ9	B5R541	Arg154 Gln156 Leu278 Asp225 Glu251 Pro329 not aligned Phe48 Arg84
Q8EMJ9	P27099	Lys163 Lys165 Ser247 Asp194 Glu220 Met298 Ser49 Glu61 not aligned
Q8EMJ9	C9A1P5	Arg153 Gln155 Leu260 Asp207 Glu233 Pro311 not aligned Glu47 Arg83
Q8EMJ9	P42428	Lys156 Lys158 Gly240 Asp187 Glu213 Phe291 Thr42 Glu54 not aligned
Q8EMJ9	O33946	Lys167 Lys169 Ile249 Asp198 Glu224 Met300 Thr53 Glu65 not aligned
Q8EMJ9	P95608	Lys167 Lys169 Ser251 Asp198 Glu224 Ser302 Val53 Glu65 not aligned
Q8EMJ9	A0Q5S7	Lys161 Lys163 Ser246 Asp191 Glu219 Met297 Ala51 Gln61 not aligned
Q8EMJ9	P83763	Lys163 Lys165 Ser247 Asp194 Glu220 Met298 Ser49 Glu61 not aligned
Q8EMJ9	P32426	Arg148 Gln150 Val263 Asp210 Glu236 Ala314 not aligned Leu42 Arg78
Q8EMJ9	Q9RNZ9	Lys163 Lys165 Ser247 Asp194 Glu220 Met298 Ser49 Glu61 not aligned
Q8EMJ9	O33949	Lys169 Lys171 Ala253 Asp200 Glu226 Met304 Thr55 Glu67 not aligned
Q8EMJ9	B5QBD4	Arg152 Gln154 Leu276 Asp223 Glu249 Pro327 not aligned Phe46 Arg82