M-CSA Mechanism and Catalytic Site Atlas

Asparagine synthase (glutamine-hydrolysing) (M-CSA:302)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P22106

Reference Sequence	Homologue	Cys2 (N-term) Thr322 Leu51 (main-C) Gly76 (main-N) Arg325 Cys2 Asn75
P22106	P22106	Cys2 Thr322 Leu51 Gly76 Arg325 Cys2 Asn75
P22106	P08243	Cys2 Thr337 Leu50 Gly76 Arg340 Cys2 Asn75
P22106	Q43011	Cys2 Thr316 Leu51 Gly76 Arg319 Cys2 Asn75
P22106	P49078	Cys2 Thr316 Leu51 Gly76 Arg319 Cys2 Asn75
P22106	P49094	Cys2 Thr316 Leu51 Gly76 Arg319 Cys2 Asn75
P22106	Q1LZA3	Cys2 Thr337 Leu50 Gly76 Arg340 Cys2 Asn75
P22106	Q5R6W9	Cys2 Thr337 Leu50 Gly76 Arg340 Cys2 Asn75
P22106	Q61024	Cys2 Thr337 Leu50 Gly76 Arg340 Cys2 Asn75
P22106	Q5ZJU3	Cys2 Thr337 Leu50 Gly76 Arg340 Cys2 Asn75
P22106	P78753	Cys2 Thr329 Leu51 Gly76 Arg332 Cys2 Asn75
P22106	P49088	Cys2 Thr337 Leu50 Gly76 Arg340 Cys2 Asn75
P22106	Q54MB4	Cys2 Thr328 Leu51 Gly76 Arg331 Cys2 Asn75
P22106	Q5UQE1	Cys2 Thr334 Leu54 Gly79 Arg337 Cys2 Asn78
P22106	Q9LFU1	Cys2 Thr316 Leu51 Gly76 Arg319 Cys2 Asn75
P22106	Q10MX3	Cys2 Thr317 Leu51 Gly76 Arg320 Cys2 Asn75
P22106	Q58516	Cys2 not aligned Leu69 Gly93 not aligned Cys2 Asn92
P22106	O05272	Cys2 not aligned Leu51 Gly78 not aligned Cys2 Asn77
P22106	P54420	Cys2 not aligned Leu53 Gly78 not aligned Cys2 Asn77
P22106	Q9LV77	Cys2 Thr316 Leu51 Gly76 Arg319 Cys2 Asn75
P22106	B6HLP8	Cys2 not aligned Leu61 Gly87 not aligned Cys2 Asn86
P22106	P9WN33	Cys2 not aligned Leu61 Gly90 not aligned Cys2 Asn89
P22106	Q58456	Cys2 not aligned Leu53 Gly93 not aligned Cys2 Asn92
P22106	P42113	Cys2 not aligned Leu53 Gly78 not aligned Cys2 Asn77
P22106	Q04489	Cys2 not aligned Leu72 Gly95 not aligned Cys2 Asn94
P22106	Q9XB61	Ser2 Gly318 not aligned Gly57 not aligned Ser2 Ile56
P22106	P17714	Cys2 Thr337 Leu50 Gly76 Arg340 Cys2 Asn75
P22106	P19252	Cys2 Thr316 Leu51 Gly76 Arg319 Cys2 Asn75
P22106	P49093	Cys2 Thr316 Leu51 Gly76 Arg319 Cys2 Asn75
P22106	P49090	Cys2 Thr340 Leu50 Gly75 Arg343 Cys2 Asn74
P22106	P49091	Cys2 Thr317 Leu51 Gly76 Arg320 Cys2 Asn75
P22106	O24338	Cys2 Thr316 Leu51 Gly76 Arg319 Cys2 Asn75
P22106	P49089	Cys2 Thr341 Leu50 Gly75 Arg344 Cys2 Asn74
P22106	P49092	Cys2 Thr316 Leu51 Gly76 Arg319 Cys2 Asn75
P22106	P64248	Cys2 not aligned Leu61 Gly90 not aligned Cys2 Asn89
P22106	P19251	Cys2 Thr317 Leu51 Gly76 Arg320 Cys2 Asn75
P22106	O24661	Cys2 Thr316 Leu51 Gly76 Arg319 Cys2 Asn75
P22106	P31752	Cys2 Thr316 Leu51 Gly76 Arg319 Cys2 Asn75
P22106	P9WN32	Cys2 not aligned Leu61 Gly90 not aligned Cys2 Asn89
P22106	P19891	Cys2 Thr337 Leu50 Gly76 Arg340 Cys2 Asn75