3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (M-CSA:280)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P12694

Reference Sequence Homologue His336 Ser337 Ser207 (main-C) Glu121
P12694
FunTreePfam
P21873
FunTreePfam
His272 Thr273 Ile143 Ser66
P12694
FunTreePfam
P08559
FunTreePfam
His292 Ser293 Gly165 Gln80
P12694
FunTreePfam
P12694
FunTreePfam
His336 Ser337 Ser207 Glu121
P12694
FunTreePfam
P21881
FunTreePfam
His274 Thr275 Ile145 Ser68
P12694
FunTreePfam
O66112
FunTreePfam
His275 Ser276 Gly146 Gln58
P12694
FunTreePfam
P37940
FunTreePfam
His252 Ser253 Ser123 Leu35
P12694
FunTreePfam
Q9R9N5
FunTreePfam
His271 Ser272 Gly142 Gln55
P12694
FunTreePfam
P50136
FunTreePfam
His333 Ser334 Ser204 Glu118
P12694
FunTreePfam
P75390
FunTreePfam
His262 Thr263 Ile133 Val56
P12694
FunTreePfam
Q5SLR4
FunTreePfam
His273 Ser274 Ser144 Ile57
P12694
FunTreePfam
P47516
FunTreePfam
His262 Thr263 Ile133 Val56
P12694
FunTreePfam
Q84JL2
FunTreePfam
His364 Ser365 Ala235 Glu149
P12694
FunTreePfam
Q5HQ76
FunTreePfam
His273 Thr274 Ile144 Ser67
P12694
FunTreePfam
Q9I1M2
FunTreePfam
His312 Ser313 Gly182 Thr96
P12694
FunTreePfam
P11960
FunTreePfam
His332 Ser333 Ser203 Glu117
P12694
FunTreePfam
Q54M22
FunTreePfam
His325 Ser326 Ser195 Asp109
P12694
FunTreePfam
F4KIN4
FunTreePfam
His134 Ser135 not aligned not aligned
P12694
FunTreePfam
O45924
FunTreePfam
His319 Ser320 Ser190 Asp104
P12694
FunTreePfam
A5A6H9
FunTreePfam
His336 Ser337 Ser207 Glu121
P12694
FunTreePfam
P9WIS3
FunTreePfam
His269 Thr270 Val140 Asn63
P12694
FunTreePfam
Q9LPL5
FunTreePfam
His364 Ser365 Ser235 Glu149
P12694
FunTreePfam
P11178
FunTreePfam
His346 Ser347 Ser217 Glu131
P12694
FunTreePfam
O31404
FunTreePfam
His251 Phe252 Gly122 Glu35
P12694
FunTreePfam
Q654V6
FunTreePfam
His300 Ser301 Gly174 Ser87
P12694
FunTreePfam
A7MB35
FunTreePfam
His292 Ser293 Gly165 Gln80
P12694
FunTreePfam
P52903
FunTreePfam
His293 Ser294 Gly167 Ser80
P12694
FunTreePfam
P35487
FunTreePfam
His293 Ser294 Gly166 Gln81
P12694
FunTreePfam
P29803
FunTreePfam
His290 Ser291 Gly163 Gln78
P12694
FunTreePfam
P16387
FunTreePfam
His312 Ser313 Gly185 Ala100
P12694
FunTreePfam
Q7XTJ3
FunTreePfam
His322 Ser323 Ala184 Gln97
P12694
FunTreePfam
Q8H1Y0
FunTreePfam
His295 Ser296 Gly169 Ser82
P12694
FunTreePfam
Q5R490
FunTreePfam
His292 Ser293 Gly165 Gln80
P12694
FunTreePfam
Q9ZDR4
FunTreePfam
His250 Ser251 Gly121 Gln34
P12694
FunTreePfam
Q06437
FunTreePfam
His293 Ser294 Gly166 Gln81
P12694
FunTreePfam
Q6Z5N4
FunTreePfam
His292 Ser293 Gly166 Ser79
P12694
FunTreePfam
O24457
FunTreePfam
His325 Ser326 Ala190 Gln103
P12694
FunTreePfam
Q54C70
FunTreePfam
His283 Ser284 Gly156 Gly71
P12694
FunTreePfam
P52899
FunTreePfam
His286 Ser287 Gly159 Asn74
P12694
FunTreePfam
P29804
FunTreePfam
His291 Ser292 Gly164 Gln79
P12694
FunTreePfam
P52901
FunTreePfam
His291 Ser292 Gly165 Ser78
P12694
FunTreePfam
Q10489
FunTreePfam
His309 Ser310 Gly182 Ala97
P12694
FunTreePfam
A5A6L0
FunTreePfam
His292 Ser293 Gly165 Gln80
P12694
FunTreePfam
P27745
FunTreePfam
His254 Phe255 Gly125 Val38
P12694
FunTreePfam
O13366
FunTreePfam
His304 Ser305 Gly177 Ala92
P12694
FunTreePfam
P35486
FunTreePfam
His292 Ser293 Gly165 Gln80
P12694
FunTreePfam
P26284
FunTreePfam
His292 Ser293 Gly165 Gln80
P12694
FunTreePfam
P09060
FunTreePfam
His312 Ser313 Gly182 Val96
P12694
FunTreePfam
P52900
FunTreePfam
His265 Ser266 Gly138 Gln53
P12694
FunTreePfam
P52902
FunTreePfam
His299 Ser300 Gly173 Ser86
P12694
FunTreePfam
Q72GU1
FunTreePfam
His273 Ser274 Ser144 Ile57
P12694
FunTreePfam
Q5HGZ1
FunTreePfam
His273 Thr274 Ile144 Ser67
P12694
FunTreePfam
P26267
FunTreePfam
His288 Ser289 Gly161 Asn76
P12694
FunTreePfam
Q8HXY4
FunTreePfam
His336 Ser337 Ser207 Glu121
P12694
FunTreePfam
Q1RJX4
FunTreePfam
His250 Ser251 Gly121 Gln34
P12694
FunTreePfam
Q1XDM0
FunTreePfam
His268 Ser269 Ala132 Gln45
P12694
FunTreePfam
Q4MTG0
FunTreePfam
His274 Thr275 Ile145 Ser68
P12694
FunTreePfam
P9WIS2
FunTreePfam
His269 Thr270 Val140 Asn63
P12694
FunTreePfam
P26268
FunTreePfam
His283 Ser284 Gly156 Asn71
P12694
FunTreePfam
Q8HXW9
FunTreePfam
His292 Ser293 Gly165 Gln80
P12694
FunTreePfam
Q68XA9
FunTreePfam
His250 Ser251 Gly121 Gln34
P12694
FunTreePfam
Q6GHZ2
FunTreePfam
His273 Thr274 Ile144 Ser67
P12694
FunTreePfam
P35485
FunTreePfam
His245 Thr246 Ile116 Gln39
P12694
FunTreePfam
Q4UKQ6
FunTreePfam
His250 Ser251 Gly121 Gln34
P12694
FunTreePfam
P60090
FunTreePfam
His273 Thr274 Ile144 Ser67
P12694
FunTreePfam
P51267
FunTreePfam
His266 Ser267 Ala130 Gln43
P12694
FunTreePfam
Q820A6
FunTreePfam
His273 Thr274 Ile144 Ser67
P12694
FunTreePfam
P60089
FunTreePfam
His273 Thr274 Ile144 Ser67
P12694
FunTreePfam
Q92IS3
FunTreePfam
His250 Ser251 Gly121 Gln34
P12694
FunTreePfam
Q6GAC1
FunTreePfam
His273 Thr274 Ile144 Ser67
P12694
FunTreePfam
Q8CPN3
FunTreePfam
His273 Thr274 Ile144 Ser67