M-CSA Mechanism and Catalytic Site Atlas

Membrane dipeptidase (M-CSA:168)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P16444

Reference Sequence	Homologue	Glu141 His214 His168 His235 Asp38 Asp304 His36
P16444	P16444	Glu141 His214 His168 His235 Asp38 Asp304 His36
P16444	P31429	Glu141 His214 His168 His235 Asp38 Asp304 His36
P16444	D4B2N2	Glu157 His228 His184 His249 Asp47 Asp320 His45
P16444	Q3SZM7	Glu141 His214 His168 His235 Asp38 Asp304 His36
P16444	P22412	Glu141 His214 His168 His235 Asp38 Asp304 His36
P16444	Q5U2X4	Glu193 His266 Phe220 His287 Asp96 Ser356 His94
P16444	M1VV65	Glu158 His227 His185 His248 Asp48 Asp318 His46
P16444	Q8C255	Glu190 His263 His217 His284 Asp93 Asp353 His91
P16444	C4JQN7	Glu208 His265 His221 His286 Asp97 Asp357 His95
P16444	P31428	Glu141 His214 His168 His235 Asp38 Asp304 His36
P16444	Q9DA79	Glu193 His266 Phe220 His287 Asp96 Ser356 His94
P16444	Q9H4B8	Glu196 Tyr269 Phe223 His290 Asp99 Asn359 His97
P16444	E9D269	Glu178 His250 His205 His271 Asp69 Asp342 His67
P16444	Q2UPB0	Glu190 His259 His217 His280 Asp79 Asp351 His77
P16444	P31430	Glu141 His214 His168 His235 Asp38 Asp304 His36
P16444	E5R2Q7	Glu168 His239 His195 His260 Asp58 Asp331 His56
P16444	O14124	Glu181 His250 His208 His271 Asp69 Asp342 His67
P16444	C5FK77	Glu167 His238 His194 His259 Asp57 Asp330 His55
P16444	Q4WMJ8	Glu134 His203 His161 His224 Asp25 Asp294 His23
P16444	E9CV02	Glu203 His274 His230 His295 Asp92 Asp366 His90
P16444	Q5M872	Glu189 His262 His216 His283 Asp92 Asp352 His90
P16444	O59832	Glu144 His215 His171 His236 Asp31 Asp307 His29
P16444	C7ZIE1	Glu201 His272 His228 His293 Asp92 Asp364 His90
P16444	B8LWT1	Glu208 His279 His235 His300 Asp94 Asp371 His92
P16444	Q0CS61	Glu138 His226 His165 His247 Asp29 Asp318 His27
P16444	P43477	Glu141 His214 His168 His235 Asp38 Asp304 His36
P16444	Q9H4A9	Glu188 His261 His215 His282 Asp91 Asp351 His89
P16444	Q6Q886	Glu141 His210 His168 His231 Asp28 Asp301 His26
P16444	C5PCN6	Glu206 His277 His233 His298 Asp95 Asp369 His93
P16444	Q4R7M2	Glu196 Tyr269 Phe223 His290 Asp99 Asn359 His97
P16444	C5PCZ0	Glu178 His250 His205 His271 Asp69 Asp342 His67
P16444	P07783	Glu132 His205 Trp159 His226 Asp14 not aligned His12
P16444	P27509	Glu53 His126 Trp80 His147 not aligned Asp220 not aligned
P16444	D4DEJ7	Glu157 His228 His184 His249 Asp47 Asp320 His45