M-CSA Mechanism and Catalytic Site Atlas

Cerebroside-sulfatase (M-CSA:158)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P15289

Reference Sequence	Homologue	Asn282 Ser150 Lys302 Asp29 Arg73 Lys123 His125 Cys69 (ptm) His229 Asp281 Asp30
P15289	P15289	Asn282 Ser150 Lys302 Asp29 Arg73 Lys123 His125 Cys69 His229 Asp281 Asp30
P15289	P51691	Asn318 Gly144 Lys375 Asp13 Arg55 Lys113 His115 Cys51 His211 Asp317 Asp14
P15289	P33727	Asn303 Ser179 Lys320 Asp55 Arg97 Lys147 His149 Cys93 His244 Asp302 Asp56
P15289	Q32KH8	Asn324 Gly146 Gln348 Asp15 Arg59 Lys115 His117 Cys55 His271 Asp323 Asp16
P15289	P51689	His357 Thr179 Lys381 Asp49 Arg93 Lys148 His150 Cys89 His304 Asp356 Asp50
P15289	P15589	His342 Thr164 Lys367 Asp34 Arg78 Lys133 His135 Cys74 His289 Asp341 Asp35
P15289	P08842	Gln343 Thr165 Lys368 Asp35 Arg79 Lys134 His136 Cys75 His290 Asp342 Asp36
P15289	P50473	His324 Gly203 Lys344 Asp75 Arg119 Lys171 His173 Cys115 His271 Asp323 Asp76
P15289	Q32KJ9	Asn303 Ser162 Lys333 Asp44 Arg88 Lys137 His139 Cys84 His251 Asp302 Asp45
P15289	Q32KH7	Asn299 Thr180 Lys316 Asp56 Arg98 Lys148 His150 Cys94 His240 Asp298 Asp57
P15289	Q08DD1	Asn282 Ser150 Lys302 Asp29 Arg73 Lys123 His125 Cys69 His229 Asp281 Asp30
P15289	Q5FYB0	Asn328 Thr208 Lys345 Asp84 Arg126 Lys176 His178 Cys122 His269 Asp327 Asp85
P15289	Q5FYA8	Asn324 Gly146 Lys348 Asp15 Arg59 Lys115 His117 Cys55 His271 Asp323 Asp16
P15289	Q32KH5	Asn289 Asp170 Lys310 Asp38 Arg82 Lys139 His141 Cys78 His236 Asp288 Asp39
P15289	Q5FYB1	Asn298 Thr179 Lys315 Asp55 Arg97 Lys147 His149 Cys93 His239 Asp297 Asp56
P15289	P50427	His351 Thr173 Lys376 Asp43 Arg87 Lys142 His144 Cys83 His298 Asp350 Asp44
P15289	Q8WNQ7	Asn289 Asp170 Lys310 Asp38 Arg82 Lys139 His141 Cys78 His236 Asp288 Asp39
P15289	Q32KJ6	Asn291 Asp172 Lys312 Asp40 Arg84 Lys141 His143 Cys80 His238 Asp290 Asp41
P15289	Q96EG1	Asn303 Ser162 Lys333 Asp44 Arg88 Lys137 His139 Cys84 His251 Asp302 Asp45
P15289	Q32KJ8	Asn298 Thr179 Lys315 Asp55 Arg97 Lys147 His149 Cys93 His239 Asp297 Asp56
P15289	P34059	Asn289 Asp171 Lys310 Asp39 Arg83 Lys140 His142 Cys79 His236 Asp288 Asp40
P15289	P50428	Asn281 Ser149 Lys301 Asp28 Arg72 Lys122 His124 Cys68 His228 Asp280 Asp29
P15289	Q8A2H2	Asn333 Val180 Lys362 Asp43 Arg87 Lys136 His138 Ser83 His280 Asp332 Asp44
P15289	Q32KH9	Asn303 Ser162 Lys333 Asp44 Arg88 Lys137 His139 Cys84 His251 Asp302 Asp45
P15289	P50430	Asn296 Thr172 Lys313 Asp48 Arg90 Lys140 His142 Cys86 His237 Asp295 Asp49
P15289	P51690	His354 Ser176 Lys378 Asp46 Arg90 Lys145 His147 Cys86 His301 Asp353 Asp47
P15289	Q32KI9	Asn298 Thr179 Lys315 Asp55 Arg97 Lys147 His149 Cys93 His239 Asp297 Asp56
P15289	Q3TYD4	Asn303 Ser162 Lys333 Asp44 Arg88 Lys137 His139 Cys84 His251 Asp302 Asp45
P15289	P50429	Asn302 Thr178 Lys319 Asp54 Arg96 Lys146 His148 Cys92 His243 Asp301 Asp55
P15289	Q571E4	Asn287 Asp168 Lys308 Asp36 Arg80 Lys137 His139 Cys76 His234 Asp286 Asp37
P15289	P15848	Asn301 Ser177 Lys318 Asp53 Arg95 Lys145 His147 Cys91 His242 Asp300 Asp54
P15289	P25549	Asn357 Pro243 Lys375 Asp94 Arg140 Lys188 His190 Ser136 His303 Asp356 Asp95
P15289	Q8BM89	Asn326 Thr206 Lys343 Asp82 Arg124 Lys174 His176 Cys120 His267 Asp325 Asp83
P15289	P54793	His346 Thr168 Lys370 Asp38 Arg82 Lys137 His139 Cys78 His293 Asp345 Asp39
P15289	P51688	Asn274 not aligned Arg282 Asp31 Arg74 Lys123 His125 Cys70 His181 Asp273 Asp32
P15289	O69787	His297 His145 Lys309 Asp14 Arg58 Lys102 His104 Cys54 His201 Asp296 Gln15
P15289	Q89YS5	Gln374 Asp176 Lys386 Asp61 Arg105 Lys149 His151 Ser101 His223 Asp373 Asp62
P15289	P77318	Asn346 Asp223 Lys364 Asp66 Arg136 Lys183 His185 Ser132 His286 Asp345 Asp67
P15289	Q9C0V7	Asn328 Ala154 Lys382 Asp20 Arg62 Lys123 His125 Cys58 His220 Asp327 Asp21
P15289	Q8BFR4	Asn319 Asn175 Lys332 Asp47 Arg87 Lys141 not aligned Cys83 His227 Asp318 Asp48
P15289	Q32KJ2	His312 Thr146 Lys324 Asp40 Arg84 Lys128 not aligned Cys80 His206 Asp311 Ser41
P15289	Q8XNV1	His303 Leu143 Lys315 Asp11 Arg55 Lys100 His102 Cys51 His210 Asp302 Gln12
P15289	Q1LZH9	Asn335 Asn191 Lys348 Asp63 Arg103 Lys157 not aligned Cys99 His243 Asp334 Asp64
P15289	Q5ZK90	His315 Thr147 Lys327 Asp41 Arg85 Lys129 not aligned Cys81 His209 Asp314 Ser42
P15289	Q6UWY0	His314 Thr146 Lys326 Asp40 Arg84 Lys128 not aligned Cys80 His208 Asp313 Ser41
P15289	P15586	Asn327 Asn183 Lys340 Asp55 Arg95 Lys149 not aligned Cys91 His235 Asp326 Asp56
P15289	Q08890	His337 Ala182 Lys349 Asp47 Arg90 Lys137 His140 Cys86 His231 Asp336 Asp48
P15289	Q32KH0	His318 Thr150 Lys330 Asp44 Arg88 Lys132 not aligned Cys84 His212 Asp317 Ser45
P15289	Q148F3	His318 Thr150 Lys330 Asp44 Arg88 Lys132 not aligned Cys84 His212 Asp317 Ser45
P15289	P22304	His335 Ala180 Lys347 Asp45 Arg88 Lys135 His138 Cys84 His229 Asp334 Asp46
P15289	Q0TUK6	His303 Leu143 Lys315 Asp11 Arg55 Lys100 His102 Cys51 His210 Asp302 Gln12
P15289	P50426	Asn334 Asn190 Lys347 Asp62 Arg102 Lys156 not aligned Cys98 His242 Asp333 Asp63
P15289	P14000	His309 Thr188 Lys329 Asp60 Arg104 Lys156 His158 Cys100 His256 Asp308 His61
P15289	Q60HH5	His354 Ser176 Lys378 Asp46 Arg90 Lys145 His147 Cys86 His301 Asp353 Asp47
P15289	P20713	Asn330 Asn163 Lys383 Asp34 Arg76 Lys132 His134 Ser72 His224 Asp329 Asp35
P15289	Q9X759	Asn330 Asn163 Lys383 Asp34 Arg76 Lys132 His134 Ser72 His224 Asp329 Asp35
P15289	Q0IHJ2	His316 Thr148 Lys328 Asp42 Arg86 Lys130 not aligned Cys82 His210 Asp315 Ala43
P15289	Q9VEX0	His328 Asn181 Lys341 Asp62 Arg102 Lys153 not aligned Cys98 His236 Asp327 Asp63