M-CSA Mechanism and Catalytic Site Atlas

Peptidylglycine monooxygenase (M-CSA:135)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P14925

Reference Sequence	Homologue	His107 His108 Gln170 His172 His244 Met314 His242
P14925	P14925	His107 His108 Gln170 His172 His244 Met314 His242
P14925	Q05754	Tyr52 His53 Glu97 Glu99 not aligned Thr231 not aligned
P14925	Q08CS6	Phe34 Ser35 Gly78 Thr80 not aligned Thr205 not aligned
P14925	P10731	His102 His103 Gln165 His167 His239 Met309 His237
P14925	Q2Q1W2	Val123 Val124 Gln400 Glu402 not aligned not aligned not aligned
P14925	Q68CI2	Tyr42 Arg43 Glu87 Glu89 not aligned Thr220 not aligned
P14925	P97467	His106 His107 Gln169 His171 His243 Met313 His241
P14925	P91268	not aligned not aligned not aligned not aligned not aligned Gly36 not aligned
P14925	E1BJS7	Val117 Val118 Gln400 Glu402 not aligned not aligned not aligned
P14925	Q61P40	not aligned not aligned Asp69 Asn71 not aligned Thr204 not aligned
P14925	E7FAM5	Val120 Val121 Gln356 Glu358 not aligned not aligned not aligned
P14925	P15101	Phe42 His43 Glu87 Glu89 not aligned Thr221 not aligned
P14925	Q9XTA0	Tyr42 Arg43 Glu87 Glu89 not aligned Thr221 not aligned
P14925	D3ZVM4	Val122 Val123 Gln387 Glu389 not aligned not aligned not aligned
P14925	Q64237	Tyr53 His54 Glu98 Glu100 not aligned Thr232 not aligned
P14925	Q5TZ24	His29 Ser30 Ala71 Ser73 not aligned Thr203 not aligned
P14925	P83388	His75 His76 Gln140 His142 His212 Met282 His210
P14925	Q9XTQ6	not aligned not aligned Asp141 Asn143 not aligned Thr276 not aligned
P14925	Q95XM2	His66 His67 Gln140 His142 His209 Met284 His207
P14925	Q98ST7	His27 Val28 Gly69 Ala71 not aligned Thr201 not aligned
P14925	Q6UVY6	His27 Arg28 Ala69 Ala71 not aligned Thr201 not aligned
P14925	F6QEU4	Val104 Val105 Gln346 Glu348 not aligned not aligned not aligned
P14925	Q1PSW8	Val122 Val123 Gln387 Glu389 not aligned not aligned not aligned
P14925	Q1PRL4	Val118 Val119 Gln408 Glu410 not aligned not aligned not aligned
P14925	P09172	Tyr49 His50 Glu94 Glu96 not aligned Thr228 not aligned
P14925	P19021	His102 His103 Gln165 His167 His239 Met309 His237
P14925	Q9W1L5	not aligned not aligned not aligned not aligned not aligned Gly59 not aligned
P14925	Q9V5E1	not aligned not aligned not aligned not aligned not aligned Gly67 not aligned
P14925	P12890	His105 His106 Gln168 His170 His242 Met312 His240
P14925	O01404	His95 His96 Gln170 His172 His243 Met317 His241
P14925	P08478	His103 His104 Gln166 His168 His240 Met310 His238
P14925	Q9VUY0	Arg46 Asn47 Arg90 Ala92 not aligned Thr230 not aligned