M-CSA Mechanism and Catalytic Site Atlas

2,4-dienoyl-CoA reductase (NADPH) (M-CSA:108)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P42593

Reference Sequence	Homologue	His253 Arg215 Gln340 Glu165 Tyr167
P42593	P42593	His253 Arg215 Gln340 Glu165 Tyr167
P42593	P16099	Gly266 Arg223 Val351 His173 Tyr175
P42593	Q02899	Phe297 Arg244 not aligned Asn195 Tyr197
P42593	Q9FEW9	Ser297 Arg237 not aligned His188 Tyr190
P42593	O87278	Asp260 Arg220 Tyr350 Tyr170 His172
P42593	A4J778	His254 Arg216 Gln341 Ala166 Tyr168
P42593	Q8Y4H1	Asn254 Arg214 not aligned His166 Tyr168
P42593	P54550	His255 Arg215 not aligned His167 Tyr169
P42593	Q69TH4	Arg279 Arg230 not aligned His181 Tyr183
P42593	B8NWW6	not aligned Lys221 not aligned Asn172 Tyr174
P42593	Q65HN9	Pro256 Arg216 not aligned His168 Tyr170
P42593	P54524	Ser266 Arg226 not aligned Asn172 Tyr174
P42593	P0DI08	not aligned Arg227 not aligned His178 Tyr180
P42593	W6Q2D7	not aligned Lys228 not aligned Asn179 Tyr181
P42593	Q69TH8	Arg284 Arg235 not aligned His186 Tyr188
P42593	Q69TH6	Arg285 Arg236 not aligned His187 Tyr189
P42593	Q8GYB8	Ala285 Arg237 not aligned His188 Tyr190
P42593	Q5KXG9	Pro255 Arg215 not aligned His167 Tyr169
P42593	P77258	not aligned Arg234 not aligned His185 Tyr187
P42593	Q9KCT8	Pro254 Arg214 not aligned His166 Tyr168
P42593	Q81EF6	Pro255 Arg215 not aligned His167 Tyr169
P42593	Q69TI0	Arg278 Arg229 not aligned Asn180 Tyr182
P42593	A8FEW4	Gln255 Arg215 not aligned His167 Tyr169
P42593	O94467	Lys303 Arg261 not aligned His211 Tyr213
P42593	Q84QK0	Arg283 Arg234 not aligned His185 Tyr187
P42593	Q8GYA3	Phe260 Arg212 not aligned His163 Tyr165
P42593	Q81RK6	Pro255 Arg215 not aligned His167 Tyr169
P42593	C5D427	Pro255 Arg215 not aligned His167 Tyr169
P42593	Q97E86	Pro255 Arg215 not aligned His165 Tyr167
P42593	Q03558	Phe297 Arg244 not aligned Asn195 Tyr197
P42593	B8N8Q9	Ala314 Arg264 not aligned His214 Tyr216
P42593	B9FFD2	Met295 Arg240 not aligned Asn191 Phe193
P42593	W6Q9S9	not aligned Arg221 not aligned Asn172 Tyr174
P42593	Q9FEX0	Glu266 Lys228 not aligned Ser178 Tyr181
P42593	Q8LAH7	His283 Arg235 not aligned Asn186 Tyr188
P42593	Q5ZC83	Ala343 Arg294 not aligned Asn245 His247
P42593	P40952	Phe296 Arg243 not aligned Asn194 Tyr196
P42593	P41816	Ser297 Arg244 not aligned Asn195 Tyr197
P42593	B9FFD3	Arg276 Arg217 not aligned His168 Phe170
P42593	Q9XG54	Ile287 Arg239 not aligned His190 Tyr192
P42593	Q0JMR0	Ser219 Arg169 not aligned Asn120 Tyr122
P42593	Q9FUP0	Ser298 Arg238 not aligned His189 Tyr191
P42593	Q6Z965	Ser300 Arg241 not aligned His192 Tyr194
P42593	E9AGH7	not aligned Arg238 not aligned Asn189 Tyr191
P42593	B9FSC8	Phe278 Arg230 not aligned His181 Tyr183
P42593	Q4WZ70	not aligned Lys225 not aligned Asn176 Tyr178
P42593	Q0E0C6	Val318 Arg270 not aligned Phe221 Tyr223
P42593	Q69TI2	Arg290 Arg241 not aligned Asn192 Tyr194
P42593	M1W0Y0	not aligned Lys223 not aligned Asn174 Phe176
P42593	Q6UEF0	not aligned Lys245 not aligned His195 Tyr197
P42593	C5H429	Ser294 Arg232 not aligned His183 Tyr185
P42593	A0ALF5	Asn254 Arg214 not aligned His166 Tyr168
P42593	A8C7R3	not aligned Lys223 not aligned Asn174 Phe176
P42593	A9VRT5	Pro255 Arg215 not aligned His167 Tyr169
P42593	P32382	Tyr261 Arg223 Ile349 His173 Tyr175
P42593	Q739N4	Pro255 Arg215 not aligned His167 Tyr169
P42593	P32370	Glu262 Arg222 Gly349 His171 Met174
P42593	G9F1Y9	Tyr282 Arg230 Glu370 His179 Tyr182
P42593	B7HNI1	Pro255 Arg215 not aligned His167 Tyr169
P42593	Q48303	Gly272 Arg229 Val357 His179 Tyr181
P42593	Q6ZXC1	not aligned Lys223 not aligned Asn174 Phe176
P42593	Q928C2	Asn254 Arg214 not aligned His166 Tyr168
P42593	Q6HJU1	Pro255 Arg215 not aligned His167 Tyr169
P42593	A0RD27	Pro255 Arg215 not aligned His167 Tyr169
P42593	B7ITF9	Pro255 Arg215 not aligned His167 Tyr169
P42593	B7JKM7	Pro255 Arg215 not aligned His167 Tyr169
P42593	A4IQK7	Pro255 Arg215 not aligned His167 Tyr169
P42593	C3P7Z9	Pro255 Arg215 not aligned His167 Tyr169
P42593	B7HJE9	Pro255 Arg215 not aligned His167 Tyr169
P42593	B8DBP0	Asn254 Arg214 not aligned His166 Tyr168
P42593	C1KYN8	Asn254 Arg214 not aligned His166 Tyr168
P42593	P43084	Tyr303 Arg254 not aligned His204 Tyr206
P42593	C1ERH2	Pro255 Arg215 not aligned His167 Tyr169
P42593	Q63CC9	Pro255 Arg215 not aligned His167 Tyr169
P42593	P0DN73	not aligned Arg229 not aligned Gln174 not aligned
P42593	A2TBU0	not aligned Lys223 not aligned Asn174 Phe176
P42593	B9IY25	Pro255 Arg215 not aligned His167 Tyr169
P42593	A7GNY4	Pro255 Arg215 not aligned His167 Tyr169
P42593	P19410	Thr248 Arg208 Gln337 His158 Tyr160
P42593	A7Z6E7	Gln255 Arg215 not aligned His167 Tyr169
P42593	P0DI09	not aligned Arg227 not aligned His178 Tyr180
P42593	Q71WV6	Asn254 Arg214 not aligned His166 Tyr168
P42593	A0A1U8QTA2	not aligned Arg235 not aligned Asn186 Tyr188
P42593	C3L5F3	Pro255 Arg215 not aligned His167 Tyr169