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Figure 9.
Fig. 9. A comparison of the barbed-end-targeting compounds
CD, bistramide A, and jaspisamide A as they would bind to the
hydrophobic cleft. (a) ‘Back’ view of the actin molecule
(spaghetti representation in blue). CD (orange) targets the back
half of the cleft between subdomains 1 and 3. (b) ‘Front’
view of the actin molecule. The macrocyclic ring of jaspisamide
A (green) binds to a hydrophobic patch on the front face of
actin bordering the cleft. (c) View of the hydrophobic cleft.
The binding regions of jaspisamide A and CD on actin barely
overlap. Bistramide A (cyan) spans the length of the cleft.
Apart from the present structure, this figure is based on the
crystal structures of jaspisamide A (PDB ID 1QZ6) and bistramide
A (PDB ID 2FXU) complexed with an actin monomer.
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