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Figure 9.
Figure 9. Molecular Mechanism for Conformational Changes
Occurring in the CNBD
Model of the cGMP binding and
conformational rearrangement that lead to activation of the SpIH
channel. The ligand binds to the closed channel primarily
through interactions between the β roll and the ribose and
phosphate of the cyclic nucleotide. For cGMP, threonine in the
β roll plays an important roll in stabilizing cGMP in the syn
configuration. The opening allosteric conformational change
involves the movement of the C helix relative to the β roll.
For cGMP, aspartate in the β roll stabilizes the rearrangement,
promoting channel opening.
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