Figure 9 - full size

 

Figure 9.
Figure 9. S1 site structure of the complex of WT uPA with the (a) 6-fluoro (CA-10) inhibitor and (b) the non-fluoro analog (CA-06). Short hydrogen bonds at the active site are cyan.

The above figure is reprinted by permission from Elsevier: J Mol Biol (2004, 344, 527-547) copyright 2004.