|
Figure 8.
Figure 8. Model of the arrangement of the conserved
side-chains A29, B7, and C25 of the “tetramerization” repeat
colored in green interacting via an intermolecular salt bridge
as well as a model for the effect of the Arg to Ser (colored in
red) mutation in C25 that prevents the tetramerization. The
inset the backbone of the model for the tetramerization repeat;
helices A and B from the β-chain are in white and helix C from
the α-chain is in cyan. Notice the absence of the BC loop. Each
triangle points towards the C terminus of its respective helix.
|
