|
Figure 8.
Figure 8. Model of the first zinc finger of SWI5 docked to
B-form DNA. A schematic representation of the zinc finger
structure is shown prepared as in Figure 4a. The sequence of the
DNA is that of the primary binding site of SWI5 and the two
DNA-strands are coloured differently for contrast. The protein N
and C termini and zinc ion are marked as well as the 5′ and
3′ ends of the DNA strand (dark blue) to which the additional
helix makes its closest approach. The DNA-recognition helix of
the canonical zinc finger is positioned to contact a base
triplet on the cyan strand. This arrangement positions the
additional helix near the opposite (dark blue) strand across the
major groove, at a suitable distance (≈7 å) for basic
residues on the surface of the helix to reach phosphate groups
of the DNA backbone. Figure 8. Model of the first zinc
finger of SWI5 docked to B-form DNA. A schematic representation
of the zinc finger structure is shown prepared as in [3]Figure
4a. The sequence of the DNA is that of the primary binding site
of SWI5 and the two DNA-strands are coloured differently for
contrast. The protein N and C termini and zinc ion are marked as
well as the 5′ and 3′ ends of the DNA strand (dark blue) to
which the additional helix makes its closest approach. The
DNA-recognition helix of the canonical zinc finger is positioned
to contact a base triplet on the cyan strand. This arrangement
positions the additional helix near the opposite (dark blue)
strand across the major groove, at a suitable distance (≈7
å) for basic residues on the surface of the helix to reach
phosphate groups of the DNA backbone.
|
