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Figure 8.
FIGURE 8. Potential A-ring and water mediated H-bonding
schemes for T and DHT. Predicted A-ring H-bond distances and
angles are shown based on the tetrahedral geometry of conserved
structural water HOH1 (see Footnote 3 and see Table 4).
Arrowhead with black dashed lines indicate the direction of
donated H-bonds and orange dashed lines designate potential
interactions with neighboring polar atoms of WT AR LBD bound to
T and AR-(20-30) FXXLF peptide (tan) (A); WT AR LBD bound to DHT
and GRIP-1-(740-752) LXXLL peptide (green) (42) (B); and the
superimposition of A and B (C). Superior hydrophilic properties
and a shorter distance are thought to enhance the HOH1 to T
3-keto O H-bond over that in DHT.
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