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Figure 8.
Figure 8. Interactions of cGMP with T592 of the β Roll and
I636D of the C Helix
Stereo view showing cGMP in the syn
configuration bound to HCN2-I636D. A simulated annealing F[o]
− F[c] omit map (green) is shown for cGMP and a 2F[o] − F[c]
omit map (blue) is shown for T592 and I636D. Dashed lines
indicate hydrogen-bonding interactions between the N2 amine of
the guanine ring and T592 and between the N1 and N2 amines of
the guanine ring and the carboxylate group of I636D.
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