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Figure 8.
FIGURE 8. Schematic representation of proposed mechanism
for lactonase activity of Drp35. A water molecule bound to Ca1
and Asp^138 is activated by Asp^138 and Ca1 (left). The
generated hydroxyl group attacks the carbon atom in the carbonyl
group of the substrate, and the oxygen atom whose covalent bond
is broken is protonated by Asp^236 (center).
3-(2-Hydroxyphenyl)propionic acid is generated.
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