Figure 8.
Figure 8 Comparison of the binding of inhibitor (1) to human
DHFR (violet) and pcDHFR (yellow). In each structure the
indoline ring of (1) is disordered. There are two orientations
observed in the human DHFR structure (violet) and two
orientations observed in the pcDHFR complex (green and cyan).
Diagram produced with SETOR (Evans, 1993[Evans, S. V. (1993). J.
Mol. Graph. 11, 134-138.]).
The above figure is reprinted
by permission from the IUCr:
Acta Crystallogr D Biol Crystallogr
(2004,
60,
646-655)
copyright 2004.
