Figure 8 - full size

 

Figure 8.
Figure 8. Alignment of inhibitors 1b (blue) and 2 (white). Trypsin shown by its solvent accessible surface. The inhibitors were superimposed using the atoms of amino acid residues His57, Asp102, Asp189 and Ser195 of trypsin or thrombin, respectively. Arrow indicates the location of the carboxylic groups.

The above figure is reprinted by permission from Elsevier: J Mol Biol (2001, 313, 593-614) copyright 2001.