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Figure 7.
Figure 7. Superposition of the active sites of the
alpha-class hGST A1-1 [Sinning et al 1993], human mu-class GST
M2-2 [Raghunathan et al 1994] and human hGST P1-1 crystal
structures showing the fit of the inhibitor TER-117. The
structures are colored yellow, green and mauve, respectively.
The characteristic Mu-loop of the rat enzyme and the C-terminal
helix α9 of the alpha-class enzyme are shown. Residues likely
to collide with the phenyl ring of the inhibitor are
highlighted. This Figure was generated with the program package
INSIGHT II (Molecular Simulations Inc., San Diego, CA, USA.).
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