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Figure 7.
Figure 7 A model for interaction of SDF-1 with CXCR4. A
schematic depicting the interaction of SDF-1 with the receptor
is shown. CXCR4 is shown with the seven helices represented as
cylinders, which are connected by the surface and cytoplasmic
loops. The N-terminal and C-terminal segments of the receptor,
and the N- and C-terminus of SDF-1, are annotated as N and C.
SDF-1 is shown as a MOLSCRIPT diagram. (A) indicates the
receptor and ligand separately prior to any interaction between
the two. (B) indicates interaction of the SDF-1 RFFESH loop
(site 1) with the N-terminal segment of the receptor. The
contact region is shown in blue. Two of the helices are
truncated [compare with (A)] to highlight the binding groove of
the receptor. (C) Shows the N-terminal region (site 2) of SDF-1
bound in groove at the top of the helices (orange). Binding of
the N-terminal region results in activation of the receptor,
which is depicted in (C) by the change in conformation of the
receptor helices compared with (B).
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