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Figure 7.
Sphere diagram of His-GAPDS highlighting sequence differences
between His-GAPDS and human placental GAPDH. Chain D of the
His-GAPDS-E. coli GAPDH tetramer is shown in stereo with NAD^+
represented as a blue ball and stick structure. Residue
positions that differ in sequence between human GAPDH and GAPDS
(blue) are shown as spheres. Residues that differ in sequence in
the selectivity cleft are shown as red spheres, and Tyr^98 and
Leu^99, which interact with the NAD^+ adenine, are shown as
yellow spheres.
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