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Figure 7.
Figure 7. Heterogeneity, Head Domain Contacts and Opening of
the MukBEF Ring Structures
(A) Architectural heterogeneity.
Three examples of closed ring structures, including MukB–MukEF
are schematically drawn. The portion enclosed in the dotted box
is presented in ribbon drawing in the inset.
(B) Effect of
MukEF on contacts between MukB heads. The MukEF frame in
MukB–MukEF prohibits intracomplex head domain contact.
Diffusional, intercomplex-wise head domain contact should be
infrequent (left). The MukEF frame in a higher-order complex
restricts free diffusion of MukB heads and their contacts within
the complex can be frequent (right).
(C) Ring opening.
Opening of the closed ring structures via intercomplex and
intracomplex head domain engagement is illustrated. The arrows
indicate contacts for head domain engagement. The portion of the
two MukB–MukEF rings enclosed in the dotted box is presented
in ribbon drawing in the inset. One of the two rings (left) has
an opening between its MukB head and MukF C-WHD. The
architectures of MukB–MukEF in the insets in A and C were
constructed based on the presented structures.
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