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Figure 7.
Figure 7 Role of the electrostatic effect in the mGluR
C-terminus/Tamalin PDZ domain interaction. Overall structure (A)
and a close-up view (B) of the Tamalin PDZ-mGluR5 C-terminus
complex. (A) The orientation of the PDZ dimers in the side view
is identical to that in Figure 4A. (C) Electrostatic surface
potential from approximately -10k[B] T^-1 (red) to +10k[B] T^-1
(blue). The negative charge of Glu114, which may contribute to
the electrostatic interaction with mGluR5, is indicated by an
arrow. (D) SPR analyses of the binding of the mGluRs and Tamalin
C-termini to the Glu114Lys PDZ mutant.
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