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Figure 7.
FIGURE 7. Model of how intramolecular SH3 domain/ligand
interactions and intermolecular Kalirin/Crk binding affect GEF
activity. Although our data strongly support two PXXP-binding
sites in Kal-SH3, as depicted in this model (with site 1 colored
blue and site 2 colored green), we cannot rule out a single
PXXP-binding site. The PKTP ligand is indicated by light blue
ovals, and the PLPP ligand by green ovals. Crk is colored red.
The PLSP ligand is located in spectrin repeat 3 (colored cyan).
The Sec14p domain and two N-terminal spectrin repeats in Kal8
are not shown.
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