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Figure 7.
Figure 7. Implications of the Structure for Relief of
Autoinibition of Ppp5
Structures of the Hsp90 peptide bound
TPR domains from Ppp5-TPR and Hop-TPR2A are superimposed on the
structure of the autoinhibited form of Ppp5. The probable
directions of continuation of the Hsp90 polypeptide chain are
indicated by the dashed lines. A model based on the Hop
structure suggested direct displacement of the αJ helix, which
forms part of the autoinhibitory interface. The actual structure
of the Ppp5-TPR/peptide complex suggests that such competition
does not occur, and that displacement of α7 of the domain as a
result of ligand binding instead disrupts the αJ interaction.
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