Figure 7.
FIG. 7. The proposed mechanism for the catalytic hydrolysis
of the sphingomyelin substrate by SMase I, His12, and His47
participate in the reaction as the acid and base. R and R'
represent ceramide 1-phosphate and choline, respectively. The
figure was generated using ChemSketch (www.acdlabs.com).
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2005,
280,
13658-13664)
copyright 2005.
