Figure 7.
FIG. 7. Proposed mechanism of inactivation for ALR by DCS
or LCS. DCS and LCS are converted to an identical final aromatic
adduct through transamination, transamination, and
tautomerization steps. The DCS- or LSC-bound PLP intermediate
following the transamination step can be racemized to each
counterpart by the same reaction as used for the true substrates.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2004,
279,
46153-46161)
copyright 2004.
