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Figure 7.
Figure 7. Transition between low- and high-ion
structures may be important for high conduction rates.
A, Experimentally observed conformational change
when the occupancy in the selectivity filter changes
from 1.0 to 2.0 ions. B, In a hypothetical case, the
selectivity filter is held in a pre-formed, high-ion
structure. Two ions will bind with lower affinity if
binding energy is used to perform work to change the
protein's conformation.
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